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18F-氟代脱氧葡萄糖正电子发射断层显像/计算机断层扫描（18F-FDG PET/CT）影像组学在肺部疾病管理中的标准化进展与应用综述

A review on advances in F-FDG PET/CT radiomics standardisation and application in lung disease management.

作者信息

Anan Noushin, Zainon Rafidah, Tamal Mahbubunnabi

机构信息

Department of Biomedical Imaging, Advanced Medical and Dental Institute, Universiti Sains Malaysia, SAINS@BERTAM, 13200, Kepala Batas, Pulau Pinang, Malaysia.

School of Physics, Universiti Sains Malaysia, 11800, Gelugor, Pulau Pinang, Malaysia.

出版信息

Insights Imaging. 2022 Feb 5;13(1):22. doi: 10.1186/s13244-021-01153-9.

DOI:10.1186/s13244-021-01153-9
PMID:35124733
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8817778/
Abstract

Radiomics analysis quantifies the interpolation of multiple and invisible molecular features present in diagnostic and therapeutic images. Implementation of 18-fluorine-fluorodeoxyglucose positron emission tomography/computed tomography (F-FDG PET/CT) radiomics captures various disorders in non-invasive and high-throughput manner. F-FDG PET/CT accurately identifies the metabolic and anatomical changes during cancer progression. Therefore, the application of F-FDG PET/CT in the field of oncology is well established. Clinical application of F-FDG PET/CT radiomics in lung infection and inflammation is also an emerging field. Combination of bioinformatics approaches or textual analysis allows radiomics to extract additional information to predict cell biology at the micro-level. However, radiomics texture analysis is affected by several factors associated with image acquisition and processing. At present, researchers are working on mitigating these interrupters and developing standardised workflow for texture biomarker establishment. This review article focuses on the application of F-FDG PET/CT in detecting lung diseases specifically on cancer, infection and inflammation. An overview of different approaches and challenges encountered on standardisation of F-FDG PET/CT technique has also been highlighted. The review article provides insights about radiomics standardisation and application of F-FDG PET/CT in lung disease management.

摘要

放射组学分析可量化诊断和治疗图像中存在的多种不可见分子特征的插值。18氟脱氧葡萄糖正电子发射断层扫描/计算机断层扫描（F-FDG PET/CT）放射组学的应用以非侵入性和高通量方式捕捉各种疾病。F-FDG PET/CT能够准确识别癌症进展过程中的代谢和解剖学变化。因此，F-FDG PET/CT在肿瘤学领域的应用已得到充分确立。F-FDG PET/CT放射组学在肺部感染和炎症方面的临床应用也是一个新兴领域。生物信息学方法或文本分析的结合使放射组学能够提取额外信息，以在微观层面预测细胞生物学。然而，放射组学纹理分析受到与图像采集和处理相关的几个因素的影响。目前，研究人员正在努力减轻这些干扰因素，并开发用于建立纹理生物标志物的标准化工作流程。这篇综述文章重点关注F-FDG PET/CT在检测肺部疾病，特别是癌症、感染和炎症方面的应用。还强调了F-FDG PET/CT技术标准化过程中遇到的不同方法和挑战。这篇综述文章提供了有关放射组学标准化以及F-FDG PET/CT在肺部疾病管理中的应用的见解。

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