甘油三酯/高密度脂蛋白胆固醇比值与新型冠状病毒肺炎死亡率相关：一项中国的回顾性研究
Triglyceride/High-Density Lipoprotein Cholesterol Ratio is Associated with the Mortality of COVID-19: A Retrospective Study in China.
作者信息
Peng Fei, Lei Si, Zhang Quan, Zhong Yanjun, Wu Shangjie
机构信息
Department of Respiratory Medicine, The Second Xiangya Hospital of Central South University, Changsha, People's Republic of China.
Department of Critical Care Medicine, The Second Xiangya Hospital of Central South University, Changsha, People's Republic of China.
出版信息
Int J Gen Med. 2022 Jan 31;15:985-996. doi: 10.2147/IJGM.S346690. eCollection 2022.
BACKGROUND
Triglyceride to high density lipoprotein cholesterol ratio (TG/HDL-c) is crucial when researching metabolic and vascular diseases, and its involvement in COVID-19 was sparsely elaborated on. The purpose of the study was to explore the inflammatory associations between the TG/HDL-c ratio and COVID-19 prognosis.
METHODS
A total of 262 COVID-19 patients consisting of 244 survivors and 18 non-survivors were retrospectively investigated. The clinical features and baseline hematological parameters were recorded and analyzed. The receiver operating characteristic curve (ROC) was used to explore the role of TG/HDL-c in predicting the mortality of COVID-19, the Spearman's rank correlation coefficients were used to measure the correlation between TG/HDL-c and inflammatory indicators, and the Kaplan-Meier (KM) curve was used to estimate the survival of COVID-19 patients with high and low TG/HDL-c ratio. Logistic regression analyses were performed to investigate the role of TG/HDL-c ratio on mortality of COVID-19 with no underlying diseases.
RESULTS
Compared with the survivors, the non-survivors of COVID-19 had significantly higher levels of white blood cells (4.7 vs 13.0 × 10/L; < 0.001), neutrophils (3.0 vs 11.6 × 10/L; < 0.001), C-reactive proteins (15.7 vs 76.7 mg/L; < 0.001) and TG/HDL-c ratio (1.4 vs 2.5; = 0.001). The ROC curve [area under the curve (AUC), 0.731; 95% confidence interval (), 0.609-0.853; = 0.001] suggested that the TG/HDL-c ratio could predict the mortality of COVID-19. The TG/HDL-c ratio was positively correlated with white blood cells ( = 0.255, < 0.001), neutrophils ( = 0.243, < 0.001) and C-reactive proteins ( = 0.170, < 0.006). Patients with high TG/HDL-c ratio showed a worse survival compared with those with low TG/HDL-c ratio (Log rank = 0.003). Moreover, TG/HDL-c ratio was an independent factor in predicting the mortality of COVID-19 patients with no underlying diseases.
CONCLUSION
Our study demonstrated that TG/HDL-c ratio might potentially be a predictive marker for mortality in COVID-19 patients.
背景
甘油三酯与高密度脂蛋白胆固醇比值（TG/HDL-c）在代谢和血管疾病研究中至关重要，但其与新型冠状病毒肺炎（COVID-19）的关系鲜有阐述。本研究旨在探讨TG/HDL-c比值与COVID-19预后之间的炎症关联。
方法
回顾性调查了262例COVID-19患者，其中包括244例幸存者和18例非幸存者。记录并分析临床特征和基线血液学参数。采用受试者工作特征曲线（ROC）探讨TG/HDL-c在预测COVID-19死亡率中的作用，用Spearman等级相关系数衡量TG/HDL-c与炎症指标之间的相关性，并用Kaplan-Meier（KM）曲线评估TG/HDL-c比值高低的COVID-19患者的生存率。进行逻辑回归分析以研究TG/HDL-c比值对无基础疾病的COVID-19患者死亡率的作用。
结果
与幸存者相比，COVID-19非幸存者的白细胞水平（4.7对13.0×10⁹/L；P<0.001）、中性粒细胞水平（3.0对11.6×10⁹/L；P<0.001）、C反应蛋白水平（15.7对76.7mg/L；P<0.001）和TG/HDL-c比值（1.4对2.5；P=0.001）显著更高。ROC曲线[曲线下面积（AUC），0.731；95%置信区间（CI），0.609 - 0.853；P=0.001]表明TG/HDL-c比值可预测COVID-19的死亡率。TG/HDL-c比值与白细胞（r=0.255，P<0.001）、中性粒细胞（r=0.243，P<0.001）和C反应蛋白（r=0.170，P<0.006）呈正相关。TG/HDL-c比值高的患者与TG/HDL-c比值低的患者相比生存率更差（对数秩检验P=0.003）。此外，TG/HDL-c比值是预测无基础疾病的COVID-19患者死亡率的独立因素。
结论
我们的研究表明，TG/HDL-c比值可能是COVID-19患者死亡率的预测标志物。
Zotero 插件