Wang Jiming, Cui Shaomin, Kong Liang, Ma Bin, Gu Jianhua
Department of Anesthesiology, Jinan People's Hospital Affiliated to Shandong First Medical University, Jinan 271199, Shandong, China.
J Oncol. 2022 Jan 30;2022:1662007. doi: 10.1155/2022/1662007. eCollection 2022.
. This study aimed to evaluate the robustness of propofol combined with sevoflurane in patients undergoing laparoscopic radical nephrectomy and its influence on immune function during perioperative period. A total of 140 patients who underwent laparoscopic nephrectomy in the Department of Oncology of our hospital from January 2018 to January 2020 were divided into the control group and the study group by the random number table method, with 70 cases in each group, who were given sevoflurane anesthesia and sevoflurane combined with propofol anesthesia, respectively. The anesthesia effect and perioperative immune function of the two groups of patients were compared. No remarkable difference was observed in the extubation time, breathing recovery time, and awakening time between the two groups; the extubation coughing score and postextubation restlessness score of the study group were significantly lower than those of the control group; the postoperative renal function indexes of the two groups of patients were not considerably different; after treatment, the CD3+ (%), CD4+ (%), and CD4+/CD8+ of the two groups of patients decreased significantly, with a higher level in the study group. For patients undergoing laparoscopic radical nephrectomy, the combination of propofol and sevoflurane yields a promising outcome in enhancing the anesthesia results and improving the perioperative immune function.
本研究旨在评估丙泊酚联合七氟醚用于腹腔镜根治性肾切除术患者的安全性及其对围手术期免疫功能的影响。选取2018年1月至2020年1月在我院肿瘤科行腹腔镜肾切除术的140例患者，采用随机数字表法分为对照组和研究组，每组70例，分别给予七氟醚麻醉和七氟醚联合丙泊酚麻醉。比较两组患者的麻醉效果及围手术期免疫功能。两组患者拔管时间、呼吸恢复时间及苏醒时间比较，差异无统计学意义；研究组拔管咳嗽评分及拔管后躁动评分均明显低于对照组；两组患者术后肾功能指标比较，差异无统计学意义；治疗后，两组患者CD3+（%）、CD4+（%）及CD4+/CD8+均明显降低，研究组降低幅度更大。对于行腹腔镜根治性肾切除术的患者，丙泊酚联合七氟醚在提高麻醉效果及改善围手术期免疫功能方面效果显著。
