Li Peng, Liu Xianben, Xing Wenqun, Qiu Huiling, Li Renling, Liu Shilei, Sun Haibo
Department of Thoracic Surgery, Henan Cancer Hospital, The Affiliated Cancer Hospital of Zhengzhou University, 127 Dongming Road, Jinshui District, Zhengzhou, 450008, Henan, China.
Quality and Standards Academy, Shenzhen Technology University, Shenzhen, 518000, Guangdong, China.
Mol Cell Biochem. 2022 Apr;477(4):1295-1308. doi: 10.1007/s11010-022-04353-z. Epub 2022 Feb 9.
Previous studies have reported that exosomes bearing certain microRNAs (miRNAs) are related to the physiological functions of different types of cancer cells. Our study aimed to elucidate the role of miR-200a in esophageal squamous cell carcinoma (ESCC). We observed that miR-200a expression is higher in esophageal carcinoma cells, tissues, and exosomes than in normal cells and healthy tissues. We showed that exosome-shuttled miR-200a promotes the proliferation, migration, and invasion of esophageal cells and inhibits apoptosis, thereby leading to the progression of ESCC. We showed that miR-200a exerts its effects through its interaction with Keap1, thus altering the Keap1/Nrf2 signaling pathway. Our results suggest that exosome-shuttled miR-200a might be useful as a biomarker for prognosis in patients with ESCC.
先前的研究报道，携带某些微小RNA（miRNA）的外泌体与不同类型癌细胞的生理功能相关。我们的研究旨在阐明miR-200a在食管鳞状细胞癌（ESCC）中的作用。我们观察到，与正常细胞和健康组织相比，食管癌细胞、组织和外泌体中miR-200a的表达更高。我们发现，外泌体转运的miR-200a促进食管细胞的增殖、迁移和侵袭，并抑制细胞凋亡，从而导致ESCC进展。我们发现，miR-200a通过与Keap1相互作用发挥其作用，从而改变Keap1/Nrf2信号通路。我们的结果表明，外泌体转运的miR-200a可能作为ESCC患者预后的生物标志物。
