Future Energy and Innovation Laboratory, Central European Institute of Technology, Brno University of Technology, 61200, Brno, Czech Republic.
Center for Advanced Functional Nanorobots, Dept. of Inorganic Chemistry, Faculty of Chemical Technology, University of Chemistry and Technology, 16628, Prague, Czech Republic.
Angew Chem Int Ed Engl. 2022 Mar 28;61(14):e202116090. doi: 10.1002/anie.202116090. Epub 2022 Feb 9.
Herein, a general procedure for the synthesis of multifunctional MRs, which simultaneously exhibit i) chiral, ii) magnetic, and iii) fluorescent properties in combination with iv) self-propulsion, is reported. Self-propelled Ni@Pt superparamagnetic microrockets have been functionalized with fluorescent CdS quantum dots carrying a chiral host biomolecule as β-cyclodextrin (β-CD). The "on-the-fly" chiral recognition potential of MRs has been interrogated by taking advantage of the β-CD affinity to supramolecularly accommodate different chiral biomolecules (i.e., amino acids). As a proof-of-concept, tryptophan enantiomers have been discriminated with a dual-mode (optical and electrochemical) readout. This approach paves the way to devise intelligent cargo micromachines with "built-in" chiral supramolecular recognition capabilities to elucidate the concept of "enantiorecognition-on-the-fly", which might be facilely customized by tailoring the supramolecular host-guest encapsulation.
本文报道了一种多功能磁共振（MR）的通用合成方法，该方法同时具有手性、磁性和荧光特性，并具有自推进功能。自推进的 Ni@Pt 超顺磁微火箭已用作为β-环糊精（β-CD）的手性主体生物分子的荧光 CdS 量子点功能化。利用 MR 对超分子客体分子的手性识别潜力，通过β-CD 亲和力来超分子容纳不同的手性生物分子（例如氨基酸）。作为概念验证，使用双通道（光学和电化学）读出方法对色氨酸对映体进行了区分。这种方法为设计具有“内置”手性超分子识别能力的智能货物微机器铺平了道路，以阐明“手性识别”的概念，通过定制超分子主体-客体包封，可以轻松地对其进行定制。
