Department of Ophthalmology, Chung-Ang University College of Medicine, 102 Heukseok-ro, Dongjak-gu, Seoul, 06973, Republic of Korea.
Biomedical Research Institute, Chung-Ang University Hospital, Seoul, Republic of Korea.
Sci Rep. 2022 Feb 9;12(1):2172. doi: 10.1038/s41598-022-06191-x.
Here, we investigated the different perception of dry eye symptoms between in patients with and without primary Sjogren's syndrome (pSS). In this study, 221 patients with dry eye disease (DED) without pSS (non-SS DED group) and 55 patients with DED with pSS (SS DED group) were included. The ocular discomfort was evaluated using ocular surface disease index (OSDI) questionnaire and patients were further divided into 3 severity subgroups according to OSDI scores. The OSDI score was higher in the non-SS DED group even after matching corneal erosion scores despite the ocular surface erosions and tear deficiency was worse in the SS DED group. The corneal sensitivity was nearly normal in both groups without inter-group difference (Non-SS DED group: 5.82 ± 0.54 cm, SS DED group: 5.90 ± 0.29 cm, p = 0.217). Moreover, all clinical parameters were not significantly correlated with OSDI scores in both non-SS DED group and SS DED group. In the mild and severe OSDI subgroups, the ocular surface erosions and tear deficiency were worse in the SS DED group whereas the OSDI scores were not different between groups. In conclusion, clinicians should be aware that pSS patients may complain less of their discomfort unlike their actual severe status of DED.
在这里，我们研究了原发性干燥综合征（pSS）患者和非 pSS 患者的干眼症状感知差异。本研究纳入了 221 例无 pSS 的干眼患者（非 SS DED 组）和 55 例 pSS 伴干眼患者（SS DED 组）。采用眼表疾病指数（OSDI）问卷评估眼部不适，并根据 OSDI 评分将患者进一步分为 3 个严重程度亚组。尽管角膜表面侵蚀和泪液缺乏在 SS DED 组更为严重，但非 SS DED 组的 OSDI 评分仍高于角膜侵蚀评分匹配后的 SS DED 组。两组的角膜敏感性均接近正常，组间无差异（非 SS DED 组：5.82±0.54cm，SS DED 组：5.90±0.29cm，p=0.217）。此外，非 SS DED 组和 SS DED 组的所有临床参数与 OSDI 评分均无显著相关性。在 OSDI 评分轻度和重度亚组中，SS DED 组的角膜表面侵蚀和泪液缺乏更为严重，而两组的 OSDI 评分无差异。总之，临床医生应意识到 pSS 患者的不适主诉可能不如其实际严重程度的干眼症状严重。
