James Andra H, Federspiel Jerome J, Ahmadzia Homa K
Department of Obstetrics and Gynecology Division of Maternal-Fetal Medicine Duke University Durham North Carolina USA.
Department of Obstetrics and Gynecology Division of Maternal-Fetal Medicine The George Washington University Washington District of Columbia USA.
Res Pract Thromb Haemost. 2022 Feb 6;6(1):e12656. doi: 10.1002/rth2.12656. eCollection 2022 Jan.
Both the maternal and fetal outcomes of pregnancy vary greatly according to a pregnant woman's community and her condition. The most devastating outcome is the death of a mother. In 2017, there were ≈295,000 maternal deaths globally with dramatic differences in maternal mortality based on geographic region, country, and women's underlying conditions. Worldwide, the leading cause of maternal death is hemorrhage, comprising 94% of maternal deaths, with most cases occurring in low- or middle-income countries. Whether a hemorrhage originates from inside the uterus (80%-90%), from lacerations or incisions (10%-20%), or from an underlying coagulopathy (<1%), an acute acquired coagulopathy will evolve unless the hemorrhage is controlled. In low- or middle-income countries, the full range of resources to control hemorrhage is not available, but besides the usual obstetric measures, blood availability, hemostatic medication, and hematologic expertise are necessary to save mothers' lives. Hemostasis and thrombosis experts can address the disparities in obstetric hemorrhage outcomes not only as providers but as consultants, researchers, and advocates.
妊娠的母体和胎儿结局会因孕妇所在社区及其状况的不同而有很大差异。最严重的结局是母亲死亡。2017年,全球约有29.5万例孕产妇死亡,基于地理区域、国家和女性的基础状况,孕产妇死亡率存在巨大差异。在全球范围内,孕产妇死亡的主要原因是出血,占孕产妇死亡的94%,大多数病例发生在低收入或中等收入国家。无论出血是源于子宫内部(80%-90%)、撕裂伤或切口(10%-20%),还是潜在的凝血功能障碍(<1%),除非出血得到控制,否则都会演变成急性获得性凝血病。在低收入或中等收入国家,缺乏控制出血的全套资源,但除了常规的产科措施外,血液供应、止血药物和血液学专业知识对于挽救母亲的生命也是必要的。止血和血栓形成专家不仅可以作为提供者,还可以作为顾问、研究人员和倡导者,来解决产科出血结局方面的差异。