在晚期前列腺癌中运动可提高肌因子水平并抑制体外细胞生长。
Exercise in advanced prostate cancer elevates myokine levels and suppresses in-vitro cell growth.
机构信息
Exercise Medicine Research Institute, Edith Cowan University, Joondalup, WA, 6027, Australia.
School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, 6027, Australia.
出版信息
Prostate Cancer Prostatic Dis. 2022 Mar;25(1):86-92. doi: 10.1038/s41391-022-00504-x. Epub 2022 Feb 12.
BACKGROUND
Altering the systemic milieu through exercise has been proposed as a potential mechanism underlying exercise-driven tumour suppression. It is not yet known whether men with advanced prostate cancer can elicit such adaptations following a program of exercise. The purpose is to examine myokine levels of serum acquired from metastatic castrate-resistant prostate cancer (mCRPC) patients recruited to the INTERVAL-GAP4 trial before and after 6 months of exercise and its tumour-suppressive effect.
METHODS
Twenty-five men with mCRPC (age = 74.7 ± 7.1 yrs) were randomised to supervised multimodal (aerobic and resistance) exercise (EX) or self-directed exercise control group (CON). Body composition was assessed using dual-energy x-ray absorptiometry (DXA), and fasting blood in a rested state was collected at baseline and at 6 months. Serum levels of myokines (SPARC, OSM, decorin, IGF-1, and IGFBP-3) were measured. Serum was applied to the prostate cancer cell line DU145, and growth was assessed for 72 h.
RESULTS
No significant change in body composition was observed. Adjusted serum OSM (P = 0.050) and relative OSM (P = 0.083), serum SPARC (P = 0.022) and relative SPARC (P = 0.025) increased in EX compared to CON. The area under curve (AUC) over 72 h showed a significant reduction in DU145 growth after applying post-intervention serum from the EX vs CON (P = 0.029).
CONCLUSION
Elevated myokine expressions and greater tumour-suppressive effects of serum after 6 months of periodised and autoregulated supervised exercise was observed in men with mCRPC. Exercise-induced systemic changes may slow disease progression in men with advanced prostate cancer.
背景
通过运动改变全身环境被认为是运动抑制肿瘤的潜在机制。目前尚不清楚晚期前列腺癌患者在进行运动计划后是否能产生这种适应性。本研究旨在探讨转移性去势抵抗性前列腺癌（mCRPC）患者在接受 INTERVAL-GAP4 试验招募前和 6 个月运动后血清肌因子水平及其肿瘤抑制作用。
方法
25 名 mCRPC 男性（年龄=74.7±7.1 岁）被随机分为监督多模式（有氧和抗阻）运动（EX）或自我指导运动对照组（CON）。使用双能 X 射线吸收法（DXA）评估身体成分，在基线和 6 个月时采集空腹静息状态下的血液。测量肌因子（SPARC、OSM、decorin、IGF-1 和 IGFBP-3）的血清水平。将血清应用于前列腺癌细胞系 DU145，评估 72 小时的生长情况。
结果
未观察到身体成分的显著变化。与 CON 相比，EX 组血清 OSM（P=0.050）和相对 OSM（P=0.083）、血清 SPARC（P=0.022）和相对 SPARC（P=0.025）均升高。72 小时的曲线下面积（AUC）显示，应用干预后血清后，EX 组与 CON 组相比，DU145 生长明显减少（P=0.029）。
结论
在 mCRPC 男性中，经过 6 个月的阶段性和自主监督运动后，观察到肌因子表达升高和血清肿瘤抑制作用增强。运动引起的全身变化可能会减缓晚期前列腺癌男性的疾病进展。
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