大肠杆菌K-12的CytR调控基因的核苷酸序列。
Nucleotide sequence of the CytR regulatory gene of E. coli K-12.
作者信息
Valentin-Hansen P, Larsen J E, Højrup P, Short S A, Barbier C S
出版信息
Nucleic Acids Res. 1986 Mar 11;14(5):2215-28. doi: 10.1093/nar/14.5.2215.
Abstract
We have determined the nucleotide sequence of the cytR gene, which codes for the Cyt repressor (CytR). The coding region consists of 1023 or 1029 bp. The subunits of CytR are thus predicted to consist of 341 or 343 residues. It is shown that the N-terminal segment of the polypeptide is structurally similar to the DNA-binding region of known DNA-binding proteins. In addition, there exists an exceptionally high amino acid sequence homology between CytR and the Gal repressor, indicating a common origin of evolution.
摘要
我们已经确定了编码Cyt阻遏物（CytR）的cytR基因的核苷酸序列。编码区由1023或1029个碱基对组成。因此，预计CytR的亚基由341或343个残基组成。结果表明，该多肽的N端片段在结构上与已知DNA结合蛋白的DNA结合区域相似。此外，CytR与Gal阻遏物之间存在极高的氨基酸序列同源性，表明它们有共同的进化起源。
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