Laboratory of Plant Molecular Pathology and Functional Genomics, Department of Plant Biosciences, School of Applied Biosciences, College of Agriculture & Life Science, Kyungpook National University, Daegu 41944, Korea.
Laboratory of Cell Biology, Department of Entomology, Abdul Wali Khan University, Mardan 23200, Khyber Pakhtunkhwa, Pakistan.
Int J Mol Sci. 2022 Jan 31;23(3):1657. doi: 10.3390/ijms23031657.
Nitric oxide (NO) is a versatile signaling molecule with diverse roles in plant biology. The NO-mediated signaling mechanism includes post-translational modifications (PTMs) of target proteins. There exists a close link between NO-mediated PTMs and the proteasomal degradation of proteins via ubiquitylation. In some cases, ubiquitin-mediated proteasomal degradation of target proteins is followed by an NO-mediated post-translational modification on them, while in other cases NO-mediated PTMs can regulate the ubiquitylation of the components of ubiquitin-mediated proteasomal machinery for promoting their activity. Another pathway that links NO signaling with the ubiquitin-mediated degradation of proteins is the N-degron pathway. Overall, these mechanisms reflect an important mechanism of NO signal perception and transduction that reflect a close association of NO signaling with proteasomal degradation via ubiquitylation. Therefore, this review provides insight into those pathways that link NO-PTMs with ubiquitylation.
一氧化氮（NO）是一种多功能的信号分子，在植物生物学中具有多种作用。NO 介导的信号机制包括靶蛋白的翻译后修饰（PTMs）。NO 介导的 PTMs 与通过泛素化的蛋白质的蛋白酶体降解之间存在密切联系。在某些情况下，靶蛋白的泛素介导的蛋白酶体降解之后是 NO 介导的对它们的翻译后修饰，而在其他情况下，NO 介导的 PTMs 可以调节泛素介导的蛋白酶体机制的组件的泛素化，以促进其活性。将 NO 信号与蛋白质的泛素介导的降解联系起来的另一个途径是 N-降解途径。总的来说，这些机制反映了 NO 信号感知和转导的一个重要机制，反映了 NO 信号与通过泛素化的蛋白酶体降解的密切关联。因此，本综述提供了对将 NO-PTMs 与泛素化联系起来的那些途径的深入了解。
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