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评价蜂胶和蜂毒在γ射线诱导大鼠氧化应激中的作用。

Evaluating the role of propolis and bee venom on the oxidative stress induced by gamma rays in rats.

机构信息

Radioisotopes Department, Nuclear Research Center, Egyptian Atomic Energy Authority, Dokki, Giza, 12311, Egypt.

出版信息

Sci Rep. 2022 Feb 16;12(1):2656. doi: 10.1038/s41598-022-05979-1.

DOI:10.1038/s41598-022-05979-1
PMID:35173181
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8850618/
Abstract

Honeybee products consist of many substances, which have long been known for their medicinal and health-promoting properties. This study set out to appraise the protective potential of Egyptian propolis (EP) and bee venom (BV) separately or combined against total body irradiation (TBI) induced oxidative injury in rats. Besides, we assessed the bioactive components in EP and BV using HPLC and UPLC/ ESI-MS analysis in the positive ion mode. The animals were subjected to a source of gamma ionizing radiation at a dose of 6 Gy. Propolis and BV were administered independently and in combination before 14 days of γ-irradiation. Liver and kidney functions were estimated besides, DNA damage index (8- OHdG) by ELISA. Antioxidants, including glutathione (GSH), catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx) were detected. Gene expression technique investigated for BAX, BCL2, and in plasma also miR125b expression in serum of rats. Besides, the histopathological for the brain, liver, kidney, and heart were investigated. In addition, lipid peroxidation was investigated in plasma and in the previous organs. The present results provide opportunities to advance the use of bee products as promising medicinal sources.

摘要

蜂产品包含许多物质，这些物质的药用和保健特性早已为人所知。本研究旨在评估埃及蜂胶（EP）和蜂毒（BV）单独或联合应用于全身照射（TBI）诱导的大鼠氧化损伤的保护潜力。此外，我们使用 HPLC 和 UPLC/ESI-MS 分析在正离子模式下评估 EP 和 BV 中的生物活性成分。动物在 6 Gy 的γ离子辐射源下接受照射。蜂胶和 BV 在 γ 照射前 14 天分别和联合给药。测定肝肾功能，用 ELISA 测定 DNA 损伤指数（8-OHdG）。检测抗氧化剂，包括谷胱甘肽（GSH）、过氧化氢酶（CAT）、超氧化物歧化酶（SOD）和谷胱甘肽过氧化物酶（GPx）。还研究了大鼠血浆中 BAX、BCL2 的基因表达技术和血清中 miR125b 的表达。此外，还研究了大脑、肝脏、肾脏和心脏的组织病理学变化。还检测了血浆和上述器官中的脂质过氧化。目前的研究结果为将蜜蜂产品作为有前途的药用资源的应用提供了机会。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f7c0/8850618/ccd340637d98/41598_2022_5979_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f7c0/8850618/44ff240b8fa0/41598_2022_5979_Fig1_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f7c0/8850618/5a69b5403fc6/41598_2022_5979_Fig4_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f7c0/8850618/fd6a95383d94/41598_2022_5979_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f7c0/8850618/9724ba1a0d19/41598_2022_5979_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f7c0/8850618/ccd340637d98/41598_2022_5979_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f7c0/8850618/44ff240b8fa0/41598_2022_5979_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f7c0/8850618/a93f9f062b2d/41598_2022_5979_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f7c0/8850618/3a05fe8f4d39/41598_2022_5979_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f7c0/8850618/5a69b5403fc6/41598_2022_5979_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f7c0/8850618/6400a7a85108/41598_2022_5979_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f7c0/8850618/ec4ac010e7b7/41598_2022_5979_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f7c0/8850618/fd6a95383d94/41598_2022_5979_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f7c0/8850618/9724ba1a0d19/41598_2022_5979_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f7c0/8850618/ccd340637d98/41598_2022_5979_Fig9_HTML.jpg

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