Małek Agata, Strzemski Maciej, Kurzepa Joanna, Kurzepa Jacek
Department of Medical Chemistry, Medical University of Lublin, Chodźki 4a, 20-093 Lublin, Poland.
Department of Analytical Chemistry, Medical University of Lublin, Chodźki 4a, 20-093 Lublin, Poland.
Cancers (Basel). 2023 Jul 21;15(14):3714. doi: 10.3390/cancers15143714.
Honey bee venom in its composition contains many biologically active peptides and enzymes that are effective in the fight against diseases of various etiologies. The history of the use of bee venom for medicinal purposes dates back thousands of years. There are many reports in the literature on the pharmacological properties of bee venom and/or its main components, e.g., anti-arthritic, anti-inflammatory, anti-microbial or neuroprotective properties. In addition, both crude venom and melittin exhibit cytotoxic activity against a wide range of tumor cells, with significant anti-metastatic activity in pre-clinical studies. Due to the constantly increasing incidence of cancer, the development of new therapeutic strategies in oncology is a particular challenge for modern medicine. A review paper discusses the various properties of bee venom with an emphasis on its anticancer properties. For this purpose, the PubMed database was searched, and publications related to "bee", "venom", "cancer" from the last 10 years were selected.
蜜蜂毒液的成分中含有许多生物活性肽和酶，这些物质对对抗各种病因引起的疾病有效。蜜蜂毒液用于医疗目的的历史可追溯到数千年前。文献中有许多关于蜜蜂毒液及其主要成分药理特性的报道，例如抗关节炎、抗炎、抗菌或神经保护特性。此外，粗毒液和蜂毒肽对多种肿瘤细胞均表现出细胞毒性活性，在临床前研究中具有显著的抗转移活性。由于癌症发病率不断上升，肿瘤学新治疗策略的开发是现代医学面临的一项特殊挑战。一篇综述文章讨论了蜜蜂毒液的各种特性，重点是其抗癌特性。为此，检索了PubMed数据库，并选择了过去10年中与“蜜蜂”、“毒液”、“癌症”相关的出版物。
