Yoon Jaechul, Yoon Dogeon, Lee Hyeongjin, Lee JiUn, Jo SeoYul, Kym Dohern, Yim Haejun, Hur Jun, Chun Wook, Kim GeunHyung, Cho Yong Suk
Department of Burn Surgery, Hallym Burn Center, College of Medicine, Hallym University, Youngdeungpu-gu, Seoul 02747, Republic of Korea.
Burn Institute, Hangang Sacred Heart Hospital, College of Medicine, Hallym Univeristy, Youngdeungpu-gu, Seoul 02747, Republic of Korea.
Int J Biol Macromol. 2022 Apr 30;205:452-461. doi: 10.1016/j.ijbiomac.2022.02.055. Epub 2022 Feb 14.
Due to its high polyunsaturated fatty acid content, acellular fish skin has emerged as a dermal substitute for the promotion of wound healing as it decreases scar formation while providing pain relief. However, various systematic studies on acellular fish skin, such as its biophysical analysis, in vitro activities, and clinical application, have not been sufficiently investigated. In this study, we conducted a comparative study to evaluate the wound-healing ability of acellular fish skin graft (Kerecis®) with that of the widely used bovine collagen skin graft (ProHeal®). The skin grafts were evaluated not only in terms of their biophysical properties, but also their in vitro cellular activities, using fibroblasts, keratinocytes, and human endothelial cells. The clinical study evaluated wound healing in 52 patients with acute burns who underwent skin grafting on donor sites from January 2019 to December 2020. The study was conducted with two groups; while only Kerecis® was tested in one group, Kerecis® and ProHeal® were compared in the other. In both groups, the application time of the dressing material was one to two days after split-thickness skin grafting to the donor sites. The Kerecis®-treatment group experienced faster healing than the other treatment group. In particular, the average wound healing time using the Kerecis® treatment and the ProHeal® treatment was 10.7 ± 1.5 days and 13.1 ± 1.4 days, respectively. We believe that the faster healing of the Kerecis® treatment, compared to that of the ProHeal® treatment, maybe due to the synergistic effect of the unique biophysical structure and the bioactive components of acellular fish skin.
由于其高含量的多不饱和脂肪酸，脱细胞鱼皮已成为一种促进伤口愈合的真皮替代物，因为它能减少疤痕形成并缓解疼痛。然而，关于脱细胞鱼皮的各种系统研究，如生物物理分析、体外活性和临床应用，尚未得到充分研究。在本研究中，我们进行了一项比较研究，以评估脱细胞鱼皮移植物（Kerecis®）与广泛使用的牛胶原蛋白皮肤移植物（ProHeal®）的伤口愈合能力。不仅从生物物理特性方面，还使用成纤维细胞、角质形成细胞和人内皮细胞评估了皮肤移植物的体外细胞活性。临床研究评估了2019年1月至2020年12月期间在供区接受皮肤移植的52例急性烧伤患者的伤口愈合情况。该研究分为两组进行；一组仅测试Kerecis®，另一组比较Kerecis®和ProHeal®。在两组中，敷料材料的应用时间均为在供区进行中厚皮片移植后的一至两天。Kerecis®治疗组的愈合速度比另一治疗组更快。特别是，使用Kerecis®治疗和ProHeal®治疗的平均伤口愈合时间分别为10.7±1.5天和13.1±1.4天。我们认为，与ProHeal®治疗相比，Kerecis®治疗愈合更快可能是由于脱细胞鱼皮独特的生物物理结构和生物活性成分的协同作用。
