Gastroenterology Department, The First Hospital of China Medical University, Shenyang, Liaoning, China.
The 3rd Clinical Department, China Medical University, Shenyang, Liaoning, China.
BMJ Open. 2022 Feb 17;12(2):e047588. doi: 10.1136/bmjopen-2020-047588.
To investigate the incidence and characteristics of metabolic-associated fatty liver disease (MAFLD) in individuals undergoing physical examination in Liaoning Province (China).
Retrospective study.
Single centre.
Adults who underwent routine health examination at Xikang Medical Center in Liaoning Province (Shenyang, Dandong and Dalian cities) between January 2014 and December 2018.
Among the 204 394 included subjects, 71 756 were diagnosed with MAFLD, accounting for 35.28%. The total prevalence of MAFLD in Shenyang, Dandong and Dalian cities over the past 5 years was 35.8%, 40.41% and 31.7%, respectively. Men had a prevalence of 46.12%, which was higher than in women (21.80%). The percentage of MAFLD in body mass index (BMI) <23 kg/m and ≥23 kg/m was 6.49% and 53.23%, respectively. In all subjects, BMI, systolic blood pressure, diastolic blood pressure (DBP), fasting blood glucose (FBG), triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), alanine transaminase, aspartate transaminase (AST), alkaline phosphatase (ALP), γ-glutamyl transferase (GGT), blood urea nitrogen, serum creatinine (SCr), serum uric acid (SUA), haematocrit (HCT), mean corpuscular volume (MCV) and urine protein were independently associated with MAFLD (all p<0.001). In lean subjects, DBP, FBG, TG, TC, LDL-C, HDL-C, AST, ALP, GGT, SCr, SUA, HCT and MCV were independently associated with MAFLD (all p<0.001).
The prevalence of MAFLD in Liaoning Province was found to be associated with sex, cities with different economic statuses, BMI and multiple metabolic indicators.
调查中国辽宁省体检人群代谢相关脂肪性肝病（MAFLD）的发病率和特征。
回顾性研究。
单中心。
2014 年 1 月至 2018 年 12 月期间在辽宁省（沈阳、丹东和大连）禧康医疗中心进行常规健康检查的成年人。
在纳入的 204394 名受试者中，71756 人被诊断为 MAFLD，占 35.28%。过去 5 年，沈阳、丹东和大连的 MAFLD 总患病率分别为 35.8%、40.41%和 31.7%。男性患病率为 46.12%，高于女性（21.80%）。体重指数（BMI）<23kg/m²和≥23kg/m²的 MAFLD 患病率分别为 6.49%和 53.23%。在所有受试者中，BMI、收缩压、舒张压（DBP）、空腹血糖（FBG）、甘油三酯（TG）、总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）、丙氨酸氨基转移酶、天冬氨酸氨基转移酶（AST）、碱性磷酸酶（ALP）、γ-谷氨酰转移酶（GGT）、血尿素氮、血清肌酐（SCr）、血清尿酸（SUA）、红细胞压积（HCT）、平均红细胞体积（MCV）和尿蛋白均与 MAFLD 独立相关（均 p<0.001）。在瘦人群体中，DBP、FBG、TG、TC、LDL-C、HDL-C、AST、ALP、GGT、SCr、SUA、HCT 和 MCV 与 MAFLD 独立相关（均 p<0.001）。
辽宁省 MAFLD 的患病率与性别、经济状况不同的城市、BMI 和多种代谢指标有关。
