Lagares Alfonso, Castaño-Leon Ana María, Richard Marion, Tsitsopoulos Parmenion Philip, Morales Julian, Mihai Podaru, Pavlov Vladislav, Mejan Odile, de la Cruz Javier, Payen Jean François
Department of Neurosurgery, Hospital Universitario 12 de Octubre, Universidad Complutense de Madrid, Instituto de Investigación imas12, Madrid, Spain.
Department of Surgery, Facultad de Medicina, Universidad Complutense de Madrid, Madrid, Spain.
Eur J Trauma Emerg Surg. 2023 Jun;49(3):1189-1198. doi: 10.1007/s00068-022-01902-5. Epub 2022 Feb 18.
Clinical guidelines have been developed to standardize the management of mild traumatic brain injury (mTBI) in the emergency room, in particular the indication of brain CT scan and the use of blood biomarkers. The objective of this study was to determine the degree of adherence to guidelines in the management of these patients across four countries of Southern Europe.
An electronic survey including structural and general management of mTBI patients and six clinical vignettes was conducted. In-charge physicians from France, Spain, Greece and Portugal were contacted by telephone and email. Differences among countries were searched using an unconditional approach test on contingency tables.
One hundred and eighty eight physicians from 131 Hospitals (78 Spain, 36 France, 12 Greece and 5 Portugal) completed the questionnaire. There were differences regarding the in-charge specialist across these countries. There was variability in the use of guidelines and their adherence. Spain was the country with the least guideline adherence. There was a global agreement in ordering a brain CT for patients receiving anticoagulation or platelet inhibitors, and for patients with seizures, altered consciousness, neurological deficit, clinical signs of skull fracture or signs of facial fracture. Aging was not an indication for CT in French centres. Loss of consciousness and posttraumatic amnesia were considered as indications for CT more frequently in Spain than in France. These findings were in line with the data from the 6 clinical vignettes. The estimated use of CT reached around 50% of mTBI cases. The use of S100B is restricted to five French centres.
There were large variations in the guideline adherence, especially in the situations considered to order brain CT after mTBI.
已制定临床指南以规范急诊室中轻度创伤性脑损伤(mTBI)的管理,特别是脑CT扫描的指征和血液生物标志物的使用。本研究的目的是确定南欧四个国家在这些患者管理中对指南的遵循程度。
开展了一项电子调查,内容包括mTBI患者的结构和综合管理以及六个临床病例。通过电话和电子邮件联系了法国、西班牙、希腊和葡萄牙的主管医生。使用列联表的无条件方法检验来查找各国之间的差异。
来自131家医院(78家西班牙医院、36家法国医院、12家希腊医院和5家葡萄牙医院)的188名医生完成了问卷。这些国家的主管专科医生存在差异。在指南的使用及其遵循方面存在变异性。西班牙是指南遵循度最低的国家。对于接受抗凝或血小板抑制剂治疗的患者以及有癫痫发作、意识改变、神经功能缺损、颅骨骨折临床体征或面部骨折体征的患者,在开具脑CT检查方面存在全球共识。在法国的医疗中心,年龄增长不是CT检查的指征。与法国相比,西班牙更频繁地将意识丧失和创伤后遗忘视为CT检查的指征。这些发现与6个临床病例的数据一致。估计CT检查的使用率达到mTBI病例的50%左右。S100B的使用仅限于五个法国医疗中心。
在指南遵循方面存在很大差异,尤其是在mTBI后开具脑CT检查的情况方面。