全面分析趋化因子（CXCLs）在人弥漫性大 B 细胞淋巴瘤中的表达及意义。

Comprehensive analysis of the expression and significance of CXCLs in human diffuse large B-cell lymphoma.

机构信息

School of Basic Medical Sciences, Inner Mongolia Medical University, Hohhot, 010110, Inner Mongolia Autonomous Region, China.

Department of Pathology, Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia Autonomous Region, China.

出版信息

Sci Rep. 2022 Feb 18;12(1):2817. doi: 10.1038/s41598-022-06877-2.

CXCL chemokines (CXCLs) are small cytokines or signal proteins secreted by cells that have been proven to be linked to the occurrence and development of many kinds of cancer. However, the expression and diagnostic and prognostic value of CXCLs in diffuse large B-cell lymphoma (DLBCL) remain to be further studied. We obtained CXCL transcription and survival data of patients with DLBCL from Oncomine, Gene Expression Profiling Interactive Analysis (GEPIA), The Cancer Genome Atlas (TCGA), TIMER and cBioPortal databases. R software, STRING and EXCEL were used to process the data. This study discovered that the expression levels of CXCL9-14 in DLBCL were higher than those in normal tissues, while CXCL4, CXCL7 and CXCL8 were lower in tumor than in normal tissues. The expression levels of CXCL2, CXCL10 and CXCL11 were related to tumor stage. CXCL9-14 could be used as an auxiliary molecular marker for the diagnosis of DLBCL. CXCL17 might be a potential prognostic marker of DLBCL.

细胞趋化因子（CXCLs）是由细胞分泌的小细胞因子或信号蛋白，已被证明与多种癌症的发生和发展有关。然而，CXCLs 在弥漫性大 B 细胞淋巴瘤（DLBCL）中的表达及其诊断和预后价值仍有待进一步研究。我们从 Oncomine、基因表达谱交互分析（GEPIA）、癌症基因组图谱（TCGA）、TIMER 和 cBioPortal 数据库中获得了 DLBCL 患者的 CXCL 转录和生存数据。R 软件、STRING 和 EXCEL 用于处理数据。本研究发现，DLBCL 中 CXCL9-14 的表达水平高于正常组织，而 CXCL4、CXCL7 和 CXCL8 在肿瘤中的表达水平低于正常组织。CXCL2、CXCL10 和 CXCL11 的表达水平与肿瘤分期有关。CXCL9-14 可作为 DLBCL 辅助诊断的分子标志物。CXCL17 可能是 DLBCL 的潜在预后标志物。