Department of Gynecology, Guangzhou Red Cross Hospital, Guangzhou Red Cross Hospital of Jinan University, Guangzhou, Guangdong 510220, China.
Guangzhou Institute of Traumatic Surgery, Guangzhou Red Cross Hospital, Guangzhou Red Cross Hospital of Jinan University, Guangzhou, Guangdong 510220, China.
Dis Markers. 2023 Feb 6;2023:5223657. doi: 10.1155/2023/5223657. eCollection 2023.
The chemokine (C-X-C motif) ligand (CXCL) family in tumor tissue is closely related to tumor growth, metastasis, and survival. However, the differential expression profile and prognostic value of the CXCLs in ovarian cancer (OC) have not been elucidated. Therefore, we studied the expression levels and mutations of CXCLs in OC patient in TCGA and various public databases. The expression differences of CXCLs in OC cancer tissues and normal tissues were compared through the Gene Expression Profiling Interactive Analysis (GEPIA) database. The effect of CXCLs on OC prognosis was analyzed using the Kaplan-Meier curves in GEPIA database. The impact of CXCLs on immune infiltration and clinicopathological outcomes in OC was assessed using the TIMER algorithm. Compared with normal tissues, we found that eight CXCLs were significantly differentially expressed in OC. The expression levels of CXCL9 ( = 0.0201), CXCL11 ( = 0.0385), and CXCL13 ( = 0.0288) were significantly associated with tumor stage. CXCL13 was the only gene that significantly affected both disease-free survival (DFS) and overall survival (OS) in OC, and higher CXCL13 transcript levels implied longer DFS and OS. Although there was no significant impact on DFS, CXCL10 ( = 0.0079) and CXCL11 ( = 0.0011) expression levels had a significant effect on OS in OC. At the same time, CXCLs were significantly associated with several immune-infiltrating cells in OC tissues. The CXCLs were significantly associated with one or more immune-infiltrating cells in OC tissue. CXCL13 was differentially expressed in OC and significantly affected the prognosis of patients and was a potential marker of OC prognosis.
肿瘤组织中的趋化因子（C-X-C 基序）配体（CXCL）家族与肿瘤生长、转移和存活密切相关。然而，CXCL 在卵巢癌（OC）中的差异表达谱和预后价值尚未阐明。因此，我们在 TCGA 和各种公共数据库中研究了 OC 患者中 CXCL 的表达水平和突变。通过基因表达谱交互分析（GEPIA）数据库比较 OC 癌组织和正常组织中 CXCL 的表达差异。GEPIA 数据库中的 Kaplan-Meier 曲线分析 CXCL 对 OC 预后的影响。TIMER 算法评估 CXCL 对 OC 免疫浸润和临床病理结局的影响。与正常组织相比，我们发现 8 种 CXCL 在 OC 中表达差异显著。CXCL9（ = 0.0201）、CXCL11（ = 0.0385）和 CXCL13（ = 0.0288）的表达水平与肿瘤分期显著相关。CXCL13 是唯一对 OC 无病生存期（DFS）和总生存期（OS）均有显著影响的基因，CXCL13 转录水平较高意味着 DFS 和 OS 更长。虽然对 DFS 没有显著影响，但 CXCL10（ = 0.0079）和 CXCL11（ = 0.0011）的表达水平对 OC 的 OS 有显著影响。同时，CXCL 在 OC 组织中的几种免疫浸润细胞中也有显著的相关性。CXCLs 与 OC 组织中的一种或多种免疫浸润细胞显著相关。CXCL13 在 OC 中差异表达，并显著影响患者的预后，是 OC 预后的潜在标志物。
