Department of Nuclear Medicine, Manipal College of Health Professions, Manipal Academy of Higher Education, Manipal, Karnataka, India.
Department of Nuclear Medicine, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India.
Bioelectromagnetics. 2022 Apr;43(3):193-210. doi: 10.1002/bem.22396. Epub 2022 Feb 18.
Skin cancer is among the fastest-growing cancers with an excellent prognosis, if detected early. However, the current method of diagnosis by visual inspection has several disadvantages such as overlapping tumor characteristics, subjectivity, low sensitivity, and specificity. Hence, several adjunctive diagnostic techniques such as thermal imaging, optical imaging, ultrasonography, tape stripping methods, and electrical impedance imaging are employed along with visual inspection to improve the diagnosis. Electrical impedance-based skin cancer detection depends upon the variations in electrical impedance characteristics of the transformed cells. The information provided by this technique is fundamentally different from other adjunctive techniques and thus has good prospects. Depending on the stage, type, and location of skin cancer, various impedance-based devices have been developed. These devices when used as an adjunct to visual methods have increased the sensitivity and specificity of skin cancer detection up to 100% and 87%, respectively, thus demonstrating their potential to minimize unnecessary biopsies. In this review, the authors track the advancements and progress made in this technique for the detection of skin cancer, focusing mainly on the advantages and limitations in the clinical setting. © 2022 Bioelectromagnetics Society.
皮肤癌是增长最快的癌症之一，如果早期发现，预后良好。然而，目前通过视觉检查进行诊断的方法存在几个缺点，如肿瘤特征重叠、主观性、低灵敏度和特异性。因此，人们采用了几种辅助诊断技术，如热成像、光学成像、超声、胶带剥离法和电阻抗成像等，与视觉检查相结合以提高诊断效果。基于电阻抗的皮肤癌检测依赖于转化细胞的电阻抗特征的变化。该技术提供的信息与其他辅助技术有根本的不同，因此具有很好的前景。根据皮肤癌的阶段、类型和位置，已经开发出了各种基于阻抗的设备。这些设备作为视觉方法的辅助手段，将皮肤癌检测的灵敏度和特异性分别提高到了 100%和 87%，从而证明了它们有潜力最大限度地减少不必要的活检。在这篇综述中，作者主要关注临床环境中的优缺点，追踪了该技术在皮肤癌检测方面的进展和进步。© 2022 生物电磁学学会。
