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踝关节肌周细胞瘤:1例罕见病例报告及细胞遗传学研究

Ankle Myopericytoma: A Rare Case Report and Cytogenetic Study.

作者信息

Alqassab Aqilah T, Alsadah Fatimah Z, Elsharkawy Tarek, Alhamad Mohammad, Alsayed Hassan

机构信息

Pathology, King Fahd University Hospital, Dammam, SAU.

Pathology, Imam Abdulrahman Bin Faisal University, Dammam, SAU.

出版信息

Cureus. 2022 Jan 17;14(1):e21307. doi: 10.7759/cureus.21307. eCollection 2022 Jan.

DOI:10.7759/cureus.21307
PMID:35186568
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8849462/
Abstract

Myopericytoma (MPC) is an uncommon benign neoplasm of the skin and soft tissues belonging to a spectrum of tumors that are histologically recognized by their distinctive perivascular myoid cell differentiation. These distinct tumors are more prevalent among middle-aged males, and they arise more frequently in the subcutaneous tissue of the four extremities. In this paper, myopericytoma is reported in a 59-year-old Saudi male, presented with a painless small cyst involving the left ankle suspected clinically to be a ganglion cyst. Following surgical excision of the cyst, the diagnosis of myopericytoma was made based on the histopathological pattern of the disease. This paper focuses on the clinical and histopathological findings of myopericytoma and emphasizes the importance of immunohistochemistry as well as molecular testing in reaching the final diagnosis.

摘要

肌周细胞瘤(MPC)是一种皮肤和软组织的罕见良性肿瘤,属于一组肿瘤,在组织学上可通过其独特的血管周围肌样细胞分化来识别。这些独特的肿瘤在中年男性中更为常见,且更频繁地发生于四肢的皮下组织。本文报道了一名59岁的沙特男性肌周细胞瘤病例,该患者左踝出现一个无痛性小囊肿,临床怀疑为腱鞘囊肿。囊肿手术切除后,根据疾病的组织病理学模式做出了肌周细胞瘤的诊断。本文重点关注肌周细胞瘤的临床和组织病理学发现,并强调免疫组织化学以及分子检测在最终诊断中的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e45/8849462/2a90ef40724f/cureus-0014-00000021307-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e45/8849462/5ff876018a52/cureus-0014-00000021307-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e45/8849462/94fbffcf472c/cureus-0014-00000021307-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e45/8849462/83affcba888b/cureus-0014-00000021307-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e45/8849462/2a90ef40724f/cureus-0014-00000021307-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e45/8849462/5ff876018a52/cureus-0014-00000021307-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e45/8849462/94fbffcf472c/cureus-0014-00000021307-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e45/8849462/83affcba888b/cureus-0014-00000021307-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e45/8849462/2a90ef40724f/cureus-0014-00000021307-i04.jpg

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本文引用的文献

1
Myopericytoma/myopericytomatosis of the lower extremity in two young patients: a recently designated rare soft tissue neoplasm.两名年轻患者下肢的肌周细胞瘤/肌周细胞瘤病:一种新近命名的罕见软组织肿瘤。
Radiol Case Rep. 2017 Nov 13;13(1):275-280. doi: 10.1016/j.radcr.2017.10.010. eCollection 2018 Feb.
2
Primary malignant myopericytoma with cancer cachexia: Report of the first case and review of literature.伴有癌性恶病质的原发性恶性肌周细胞瘤:首例病例报告及文献复习
Medicine (Baltimore). 2017 Dec;96(49):e9064. doi: 10.1097/MD.0000000000009064.
3
Myopericytomatosis: Clinicopathologic Analysis of 11 Cases With Molecular Identification of Recurrent PDGFRB Alterations in Myopericytomatosis and Myopericytoma.
肌周细胞瘤病:11例临床病理分析及肌周细胞瘤病和肌周细胞瘤中复发性血小板衍生生长因子受体B(PDGFRB)改变的分子鉴定
Am J Surg Pathol. 2017 Aug;41(8):1034-1044. doi: 10.1097/PAS.0000000000000862.
4
Myopericytoma occurrence in the liver and stomach space: imaging performance.肝脏和胃间隙发生的肌周细胞瘤:影像学表现
BMC Cancer. 2017 Feb 20;17(1):143. doi: 10.1186/s12885-017-3146-3.
5
Recurrent Somatic PDGFRB Mutations in Sporadic Infantile/Solitary Adult Myofibromas But Not in Angioleiomyomas and Myopericytomas.散发性婴儿/孤立性成人肌纤维瘤中存在复发性体细胞PDGFRB突变,而血管平滑肌瘤和肌周细胞瘤中则不存在。
Am J Surg Pathol. 2017 Feb;41(2):195-203. doi: 10.1097/PAS.0000000000000752.
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Cutaneous Myopericytoma: A Report of 3 Cases and Review of the Literature.皮肤肌周细胞瘤:3例报告及文献复习
Dermatopathology (Basel). 2015 Feb 11;2(1):9-14. doi: 10.1159/000371875. eCollection 2015 Jan-Mar.
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