Asperbenzophenone A 和 Versicolamide C，来源于软珊瑚曲霉 SCSIO 41036 的新型真菌代谢产物。

Asperbenzophenone A and Versicolamide C, New Fungal Metabolites from the Soft Coral Derived Aspergillus sp. SCSIO 41036.

机构信息

CAS Key Laboratory of Tropical Marine Bio-Resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica/Innovation Academy of South China Sea Ecology and Environmental Engineering, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, 510301, P. R. China.

University of Chinese Academy of Sciences, 19 Yuquan Road, Beijing, 100049, P. R. China.

出版信息

Chem Biodivers. 2022 Mar;19(3):e202100925. doi: 10.1002/cbdv.202100925. Epub 2022 Feb 22.

DOI:10.1002/cbdv.202100925

PMID:35194907

Abstract

Two new compounds, asperbenzophenone A (1) and versicolamide C (5), together with fifteen known compounds were isolated from a soft coral derived fungus Aspergillus sp. SCSIO 41036. Their structures were elucidated by spectroscopic methods, ECD analysis, and by a comparison with data from the literature. In bioassay, compound 8 showed significant inhibitory activity against lipopolysaccharide-inducted nitric oxide (NO) in RAW264.7 cells at the concentration of 10 μM. Additionally, the anti-acetylcholinesterase activity assay showed that 14 exhibited weak inhibition with an IC value of 157.8 μM.

摘要

从一株来源于软珊瑚的真菌 Aspergillus sp. SCSIO 41036 中分离得到了两个新化合物，asperbenzophenone A（1）和 versicolamide C（5），以及十五个已知化合物。通过光谱方法、ECD 分析以及与文献数据的比较，确定了它们的结构。在生物测定中，化合物 8 在 10μM 浓度下对脂多糖诱导的 RAW264.7 细胞中一氧化氮（NO）的生成具有显著的抑制活性。此外，乙酰胆碱酯酶活性测定表明，化合物 14 表现出较弱的抑制作用，IC 值为 157.8μM。