Thong Eleanor P, Ghelani Drishti P, Manoleehakul Pamada, Yesmin Anika, Slater Kaylee, Taylor Rachael, Collins Clare, Hutchesson Melinda, Lim Siew S, Teede Helena J, Harrison Cheryce L, Moran Lisa, Enticott Joanne
Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University, Clayton, VIC 3168, Australia.
Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, VIC 3168, Australia.
J Cardiovasc Dev Dis. 2022 Feb 10;9(2):55. doi: 10.3390/jcdd9020055.
Cardiovascular disease, especially coronary heart disease and cerebrovascular disease, is a leading cause of mortality and morbidity in women globally. The development of cardiometabolic conditions in pregnancy, such as gestational diabetes mellitus and hypertensive disorders of pregnancy, portend an increased risk of future cardiovascular disease in women. Pregnancy therefore represents a unique opportunity to detect and manage risk factors, prior to the development of cardiovascular sequelae. Risk prediction models for gestational diabetes mellitus and hypertensive disorders of pregnancy can help identify at-risk women in early pregnancy, allowing timely intervention to mitigate both short- and long-term adverse outcomes. In this narrative review, we outline the shared pathophysiological pathways for gestational diabetes mellitus and hypertensive disorders of pregnancy, summarise contemporary risk prediction models and candidate predictors for these conditions, and discuss the utility of these models in clinical application.
心血管疾病，尤其是冠心病和脑血管疾病，是全球女性死亡和发病的主要原因。孕期发生的心脏代谢疾病，如妊娠期糖尿病和妊娠高血压疾病，预示着女性未来患心血管疾病的风险增加。因此，怀孕是在心血管后遗症出现之前检测和管理风险因素的独特机会。妊娠期糖尿病和妊娠高血压疾病的风险预测模型有助于在孕早期识别高危女性，从而及时进行干预，以减轻短期和长期不良后果。在这篇叙述性综述中，我们概述了妊娠期糖尿病和妊娠高血压疾病共同的病理生理途径，总结了这些疾病的当代风险预测模型和候选预测指标，并讨论了这些模型在临床应用中的效用。
