Ramanathan Chidambaram, Johnson Hayden, Sharma Suman, Son Wangkuk, Puppa Melissa, Rohani Saba Neyson, Tipirneni-Sajja Aaryani, Bloomer Richard J, van der Merwe Marie
College of Health Sciences, The University of Memphis, Memphis, TN 38152, USA.
Department of Biomedical Engineering, The University of Memphis, Memphis, TN 38152, USA.
Medicines (Basel). 2022 Feb 21;9(2):15. doi: 10.3390/medicines9020015.
Lengthening the daily eating period contributes to the onset of obesity and metabolic syndrome. Dietary approaches, including energy restriction and time-restricted feeding, are promising methods to combat metabolic disorders. This study explored the effect of early and late time-restricted feeding (TRF) on weight and adiposity, food consumption, glycemic control, clock gene expression, and liver metabolite composition in diurnal Nile grass rats (NGRs). Adult male and female Nile grass rats were randomly assigned to one of three groups: (1) access to a 60% high-fat (HF) diet ad-libitum (HF-AD), (2) time-restricted access to the HF diet for the first 6 h of the 12 h light/active phase (HF-AM) or (3) the second 6 h of the 12 h light/active phase (HF-PM). Animals remained on their respective protocols for six weeks. TRF reduced total energy consumption and weight gain, and early TRF (HF-AM) reduced fasting blood glucose, restored expression, and reduced liver lipid levels. Although sex-dependent differences were observed for fat storage and lipid composition, TRF improved metabolic parameters in both male and female NGRs. In conclusion, this study demonstrated that early TRF protocol benefits weight management, improves lipid and glycemic control, and restores clock gene expression in NGRs.
延长每日进食时间会导致肥胖和代谢综合征的发生。包括能量限制和限时进食在内的饮食方法是对抗代谢紊乱的有前景的方法。本研究探讨了早期和晚期限时进食（TRF）对昼夜活动的尼罗草鼠（NGRs）体重、肥胖、食物消耗、血糖控制、生物钟基因表达和肝脏代谢物组成的影响。成年雄性和雌性尼罗草鼠被随机分为三组之一：（1）随意获取60%高脂肪（HF）饮食（HF-AD），（2）在12小时光照/活动期的前6小时限时获取HF饮食（HF-AM）或（3）在12小时光照/活动期的第二个6小时（HF-PM）。动物按照各自的方案持续六周。TRF减少了总能量消耗和体重增加，早期TRF（HF-AM）降低了空腹血糖，恢复了生物钟基因表达，并降低了肝脏脂质水平。尽管在脂肪储存和脂质组成方面观察到了性别依赖性差异，但TRF改善了雄性和雌性NGRs的代谢参数。总之，本研究表明，早期TRF方案有利于体重管理，改善脂质和血糖控制，并恢复NGRs中的生物钟基因表达。
