Ganini Carlo, Amelio Ivano, Bertolo Riccardo, Candi Eleonora, Cappello Angela, Cipriani Chiara, Mauriello Alessandro, Marani Carla, Melino Gerry, Montanaro Manuela, Natale Maria Emanuela, Tisone Giuseppe, Shi Yufang, Wang Ying, Bove Pierluigi
Department of Experimental Medicine, Torvergata Oncoscience Research Centre of Excellence, TOR, University of Rome Tor Vergata, a Montpellier 1, 00133, Rome, Italy.
IDI-IRCCS, Rome, Italy.
Discov Oncol. 2021 Oct 27;12(1):45. doi: 10.1007/s12672-021-00440-7.
Serine and one-carbon unit metabolisms are essential biochemical pathways implicated in fundamental cellular functions such as proliferation, biosynthesis of important anabolic precursors and in general for the availability of methyl groups. These two distinct but interacting pathways are now becoming crucial in cancer, the de novo cytosolic serine pathway and the mitochondrial one-carbon metabolism. Apart from their role in physiological conditions, such as epithelial proliferation, the serine metabolism alterations are associated to several highly neoplastic proliferative pathologies. Accordingly, prostate cancer shows a deep rearrangement of its metabolism, driven by the dependency from the androgenic stimulus. Several new experimental evidence describes the role of a few of the enzymes involved in the serine metabolism in prostate cancer pathogenesis. The aim of this study is to analyze gene and protein expression data publicly available from large cancer specimens dataset, in order to further dissect the potential role of the abovementioned metabolism in the complex reshaping of the anabolic environment in this kind of neoplasm. The data suggest a potential role as biomarkers as well as in cancer therapy for the genes (and enzymes) belonging to the one-carbon metabolism in the context of prostatic cancer.
丝氨酸和一碳单位代谢是基本的生化途径，涉及细胞增殖、重要合成代谢前体的生物合成等基本细胞功能，总体而言与甲基的可用性有关。这两条不同但相互作用的途径，即从头胞质丝氨酸途径和线粒体一碳代谢，如今在癌症中变得至关重要。除了在诸如上皮增殖等生理状况中的作用外，丝氨酸代谢改变还与几种高度肿瘤性增殖性病变相关。相应地，前列腺癌显示出其代谢的深度重排，这是由对雄激素刺激的依赖性驱动的。一些新的实验证据描述了丝氨酸代谢中涉及的几种酶在前列腺癌发病机制中的作用。本研究的目的是分析从大型癌症标本数据集中公开可得的基因和蛋白质表达数据，以便进一步剖析上述代谢在这类肿瘤合成代谢环境复杂重塑中的潜在作用。数据表明，在前列腺癌背景下，属于一碳代谢的基因（和酶）在作为生物标志物以及癌症治疗方面具有潜在作用。
