Hayakawa Kohei, Watabe Motoki, Horikawa Hideki, Sato-Kasai Mina, Shimokawa Norihiro, Nakao Tomohiro, Kato Takahiro A
Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, Maidashi 3-1-1, Higashi-ku, Fukuoka 812-8582, Japan.
School of Business, Monash University Malaysia, Jalan Lagoon Selatan, Bandar Sunway, Subang Jaya 47500, Malaysia.
J Pers Med. 2022 Jan 19;12(2):131. doi: 10.3390/jpm12020131.
Lower serum levels of low-density lipoprotein cholesterol (LDL-C) have been suggested to indicate higher suicide risk and various psychiatric symptoms. Previously, we reported that lower serum LDL-C levels are associated with loneliness, social phobia, isolated life with little social support, and lower trust in others among young non-clinical females. Thus, we hypothesize that schizoid personality traits may be associated with lower serum LDL-C. We here verified this hypothesis using non-clinical data and clinical data with schizophrenia. Using the database from the Midlife in Japan (MIDJA), a cohort of residents living in Tokyo, we analyzed whether schizoid-related interpersonal characteristics were associated with LDL-C. In addition, we assessed the association between blood biomarkers including LDL-C and schizoid personality traits in 101 adult non-clinical volunteers. Finally, we evaluated the interaction between LDL-C and social decision making of patients with schizophrenia. In female non-clinical volunteers, serum LDL-C level was a predictive factor and negatively correlated with schizoid personality traits. Female patients with schizophrenia, whose serum LDL-C levels were lower, tended not to trust other females. The present findings suggest that LDL-C may influence schizoid personality traits in females, which provide a basis for further investigation into the biological aspects of schizoid personality disorder.
较低的血清低密度脂蛋白胆固醇（LDL-C）水平被认为表明自杀风险较高以及存在各种精神症状。此前，我们报告过低的血清LDL-C水平与年轻非临床女性的孤独感、社交恐惧症、缺乏社会支持的孤立生活以及对他人的低信任度有关。因此，我们假设分裂样人格特质可能与较低的血清LDL-C有关。我们在此使用非临床数据和精神分裂症临床数据验证了这一假设。利用来自日本中年（MIDJA）的数据库，这是一个居住在东京的居民队列，我们分析了与分裂样相关的人际特征是否与LDL-C有关。此外，我们评估了101名成年非临床志愿者中包括LDL-C在内的血液生物标志物与分裂样人格特质之间的关联。最后，我们评估了LDL-C与精神分裂症患者社会决策之间的相互作用。在女性非临床志愿者中，血清LDL-C水平是一个预测因素，且与分裂样人格特质呈负相关。血清LDL-C水平较低的女性精神分裂症患者往往不信任其他女性。目前的研究结果表明，LDL-C可能会影响女性的分裂样人格特质，这为进一步研究分裂样人格障碍的生物学方面提供了基础。
