Stuivenberg Gerrit A, Burton Jeremy P, Bron Peter A, Reid Gregor
Centre for Human Microbiome and Probiotic Research, Lawson Health Research Institute, London, ON N6A4V2, Canada.
Departments of Microbiology and Immunology and Surgery, Western University, London, ON N6A 3K7, Canada.
Microorganisms. 2022 Jan 25;10(2):278. doi: 10.3390/microorganisms10020278.
The presence of species in the maternal vaginal and fecal microbiota is arguably an evolutionary trait that allows these organisms to be primary colonizers of the newborn intestinal tract. Their ability to utilize human milk oligosaccharides fosters their establishment as core health-promoting organisms throughout life. A reduction in their abundance in infants has been shown to increase the prevalence of obesity, diabetes, metabolic disorder, and all-cause mortality later in life. Probiotic strains have been developed as supplements for premature babies and to counter some of these ailments as well as to confer a range of health benefits. The ability to modulate the immune response and produce short-chain fatty acids, particularly acetate and butyrate, that strengthen the gut barrier and regulate the gut microbiome, makes a core component of a healthy infant through adulthood.
母体阴道和粪便微生物群中该物种的存在可以说是一种进化特征，这使得这些微生物能够成为新生儿肠道的主要定植者。它们利用人乳寡糖的能力有助于它们在一生中成为促进健康的核心微生物。研究表明，婴儿体内这些微生物数量的减少会增加其日后肥胖、糖尿病、代谢紊乱和全因死亡率的患病率。已开发出益生菌菌株作为早产儿的补充剂，以对抗其中一些疾病，并带来一系列健康益处。调节免疫反应和产生短链脂肪酸（特别是乙酸盐和丁酸盐）的能力，可加强肠道屏障并调节肠道微生物群，这使得该物种成为从婴儿期到成年期健康的核心组成部分。
