Stool Microbiota Diversity Analysis of -Positive and -Negative Individuals.

is a unicellular eukaryote found in the gastrointestinal tract of both human and other animal hosts. The clinical significance of colonic colonization remains obscure. In this study, we used metabarcoding and bioinformatics analyses to identify differences in stool microbiota diversity between -positive and -negative individuals (n = 1285). Alpha diversity was significantly higher in carriers. At phylum level, Firmicutes and Bacteroidetes were enriched in carriers, while Proteobacteria were enriched in non-carriers. The genera , , , , , and were enriched in carriers, whereas , , , and were enriched in non-carriers. No difference in beta diversity was observed. Individuals with -positive stools appear to have gut microbiomes associated with eubiosis unlike those with -negative stools, whose gut microbiomes are similar to those associated with dysbiosis. The role of as an indicator organism and potential modulator of the gut microbiota warrants further scrutiny.