Liu Fan, Hu Ming, Zhang Zhijia, Xue Yang, Chen Shanshan, Hu Anqun, Zhang Lian-Hui, Zhou Jianuan
Guangdong Laboratory for Lingnan Modern Agriculture, Guangdong Province Key Laboratory of Microbial Signals and Disease Control, Integrative Microbiology Research Center, South China Agricultural University, Guangzhou, China.
Front Plant Sci. 2022 Feb 8;13:838125. doi: 10.3389/fpls.2022.838125. eCollection 2022.
Soft rot Pectobacteriaceae (SRP), typical of and , are a class of Gram-negative bacterial pathogens that cause devastating diseases on a wide range of crops and ornamental plants worldwide. Quorum sensing (QS) is a cell-cell communication mechanism regulating the expression of specific genes by releasing QS signal molecules associated with cell density, in most cases, involving in the vital process of virulence and infection. In recent years, several types of QS systems have been uncovered in pathogens to control diverse biological behaviors, especially bacterial pathogenicity and transkingdom interactions. This review depicts an integral QS regulation network of , elaborates in detail the regulation of specific QS system on different biological functions of the pathogens and hosts, aiming at providing a systematic overview of pathogenicity and interactions with hosts, and, finally, expects the future prospective of effectively controlling the bacterial soft rot disease caused by by quenching the key QS signal.
软腐果胶杆菌科（SRP）是 和 中的典型代表，是一类革兰氏阴性细菌病原体，在全球范围内对多种农作物和观赏植物造成毁灭性病害。群体感应（QS）是一种细胞间通讯机制，通过释放与细胞密度相关的QS信号分子来调节特定基因的表达，在大多数情况下，涉及毒力和感染的重要过程。近年来，在 病原体中发现了几种类型的QS系统来控制不同的生物学行为，特别是细菌致病性和跨界相互作用。本综述描绘了 的完整QS调控网络，详细阐述了特定QS系统对病原体和宿主不同生物学功能的调控，旨在系统概述 的致病性及其与宿主的相互作用，最后期望通过淬灭关键QS信号有效控制由 引起的细菌性软腐病的未来前景。
