Publications Center of Excellence, OPEN Health Communications, Evergreen, CO, USA.
Division of Endocrinology, Metabolism and Diabetes, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
J Physiol. 2022 Apr;600(7):1599-1602. doi: 10.1113/JP282189. Epub 2022 Feb 24.
Approximately 20% of the US workforce is estimated to work evening, night, or rotating shifts (i.e. “nonstandard” work hours). Shift workers have a higher risk for cardiovascular and metabolic disease compared with people who work day shifts(Anothaisintawee et al. 2016; Vetter et al. 2018), and shift work has been linked to numerous components of the metabolic syndrome, including central obesity, insulin resistance, abnormal lipid profiles(Ghiasvand et al. 2006; Karlsson, Knutsson, and Lindahl 2001), lower high-density lipoprotein(Karlsson, Knutsson, and Lindahl 2001) and elevated blood pressure(Makarem et al. 2021). It has been proposed that lifestyle factors are the culprits behind the increased risk of cardiometabolic disease in this population; however, insufficient sleep is associated with an elevated risk for developing metabolic diseases and is commonly experienced by shift workers. This CrossTalk argues that insufficient sleep is primarily responsible for the increased risk of metabolic disease in shift workers.
据估计，美国约有 20%的劳动力从事夜间、夜班或轮班工作（即“非标准”工作时间）。与上白班的人相比，轮班工作者患心血管和代谢疾病的风险更高(Anothaisintawee 等人，2016 年；Vetter 等人，2018 年)，而且轮班工作与代谢综合征的许多组成部分有关，包括中心性肥胖、胰岛素抵抗、脂质异常(Ghiasvand 等人，2006 年；Karlsson、Knutsson 和 Lindahl，2001 年)、高密度脂蛋白降低(Karlsson、Knutsson 和 Lindahl，2001 年)和血压升高(Makarem 等人，2021 年)。有人提出，生活方式因素是导致这部分人群患心血管代谢疾病风险增加的罪魁祸首；然而，睡眠不足与代谢疾病的发病风险增加有关，而这在轮班工人中很常见。本 CrossTalk 认为，睡眠不足是轮班工人代谢性疾病风险增加的主要原因。
