Depner Christopher M, Stothard Ellen R, Wright Kenneth P
Sleep and Chronobiology Laboratory, Department of Integrative Physiology, University of Colorado Boulder, 1725 Pleasant Street, Clare Small 114, Boulder, CO, 80309-0354, USA.
Curr Diab Rep. 2014 Jul;14(7):507. doi: 10.1007/s11892-014-0507-z.
Sleep and circadian rhythms modulate or control daily physiological patterns with importance for normal metabolic health. Sleep deficiencies associated with insufficient sleep schedules, insomnia with short-sleep duration, sleep apnea, narcolepsy, circadian misalignment, shift work, night eating syndrome, and sleep-related eating disorder may all contribute to metabolic dysregulation. Sleep deficiencies and circadian disruption associated with metabolic dysregulation may contribute to weight gain, obesity, and type 2 diabetes potentially by altering timing and amount of food intake, disrupting energy balance, inflammation, impairing glucose tolerance, and insulin sensitivity. Given the rapidly increasing prevalence of metabolic diseases, it is important to recognize the role of sleep and circadian disruption in the development, progression, and morbidity of metabolic disease. Some findings indicate sleep treatments and countermeasures improve metabolic health, but future clinical research investigating prevention and treatment of chronic metabolic disorders through treatment of sleep and circadian disruption is needed.
睡眠和昼夜节律调节或控制着日常生理模式，对正常的代谢健康至关重要。与睡眠时间不足、短睡眠持续时间的失眠、睡眠呼吸暂停、发作性睡病、昼夜节律失调、轮班工作、夜间饮食综合征以及睡眠相关进食障碍相关的睡眠不足，都可能导致代谢失调。与代谢失调相关的睡眠不足和昼夜节律紊乱，可能通过改变食物摄入的时间和量、扰乱能量平衡、引发炎症、损害葡萄糖耐量和胰岛素敏感性，从而导致体重增加、肥胖和2型糖尿病。鉴于代谢疾病的患病率迅速上升，认识到睡眠和昼夜节律紊乱在代谢疾病的发生、发展和发病中的作用非常重要。一些研究结果表明，睡眠治疗和对策可改善代谢健康，但未来仍需要通过治疗睡眠和昼夜节律紊乱来研究慢性代谢紊乱的预防和治疗的临床研究。
