将轴突 mRNA 运输与局部翻译相偶联，以维持细胞器的功能。
Coupling axonal mRNA transport and local translation to organelle maintenance and function.
机构信息
Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London, London, UK; UCL Queen Square Motor Neuron Disease Centre, UCL Queen Square Institute of Neurology, University College London, London, UK; UK Dementia Research Institute, University College London, London, UK.
Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London, London, UK; UCL Queen Square Motor Neuron Disease Centre, UCL Queen Square Institute of Neurology, University College London, London, UK; UK Dementia Research Institute, University College London, London, UK.
出版信息
Curr Opin Cell Biol. 2022 Feb;74:97-103. doi: 10.1016/j.ceb.2022.01.008. Epub 2022 Feb 24.
Neuronal homeostasis requires the transport of various organelles to distal compartments and defects in this process lead to neurological disorders. Although several mechanisms for the delivery of organelles to axons and dendrites have been elucidated, exactly how this process is orchestrated is not well-understood. In this review, we discuss the recent literature supporting a novel paradigm - the co-shuttling of mRNAs with different membrane-bound organelles. This model postulates that the tethering of ribonucleoprotein complexes to endolysosomes and mitochondria allows for the spatiotemporal coupling of organelle transport and the delivery of transcripts to axons. Subcellular translation of these "hitchhiking" transcripts may thus provide a proximal source of proteins required for the maintenance and function of organelles in axons.
神经元内稳态需要将各种细胞器运输到远端隔室，如果该过程出现缺陷会导致神经紊乱。尽管已经阐明了几种将细胞器递送到轴突和树突的机制，但该过程如何协调尚不清楚。在这篇综述中，我们讨论了支持一种新范例的最新文献——不同膜结合细胞器与 mRNAs 的共穿梭。该模型假定将核糖核蛋白复合物固定在内溶酶体和线粒体上，可以实现细胞器运输的时空偶联和转录本递送到轴突。这些“搭便车”转录本的亚细胞翻译因此可能为轴突中细胞器的维持和功能所需的蛋白质提供了近端来源。
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