School of Science, STEM College, RMIT University, Bundoora, 3083, Victoria, Australia.
Aquaculture Research Institute, Kindai University, Wakayama, 649-2211, Japan.
Int J Parasitol Drugs Drug Resist. 2022 Apr;18:87-102. doi: 10.1016/j.ijpddr.2022.02.001. Epub 2022 Feb 22.
Parasitic diseases are major constraints in fish mariculture. The anthelmintic praziquantel (PZQ) can effectively treat a range of flatworm parasites in a variety of fish species and has potential for broader application than its current use in the global aquaculture industry. In this review we report on PZQ's current use in the aquaculture industry and discuss its efficacy against various flatworm parasites of fish. Routes of PZQ administration are evaluated, along with issues related to palatability, pharmacokinetics and toxicity in fish, while PZQ's effects on non-target species, environmental impacts, and the development of drug-resistance are discussed.
寄生虫病是鱼类养殖的主要限制因素。驱虫药吡喹酮（PZQ）可以有效治疗多种鱼类的多种扁形虫寄生虫，其潜在应用范围比其在全球水产养殖业中的现有应用更为广泛。在这篇综述中，我们报告了 PZQ 在水产养殖业中的当前用途，并讨论了其对鱼类各种扁形虫寄生虫的疗效。评估了 PZQ 的给药途径，以及与鱼类适口性、药代动力学和毒性相关的问题，同时还讨论了 PZQ 对非目标物种的影响、环境影响和耐药性的发展。
