间歇性限时进食通过昼夜节律自噬促进长寿。
Intermittent time-restricted feeding promotes longevity through circadian autophagy.
机构信息
Life Sciences Institute, and the Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI, USA.
出版信息
Autophagy. 2022 Mar;18(3):471-472. doi: 10.1080/15548627.2022.2039524. Epub 2022 Feb 27.
Abstract
Macroautophagy/autophagy plays crucial roles in aging and the pathogenesis of age-related diseases. Studies in various animal models demonstrate the conserved requirement for autophagy-related genes in multiple anti-aging interventions. A recent study from the Shirasu-Hiza lab showed that a newly designed intermittent time-restricted feeding (iTRF) dietary regimen can robustly extend fly healthspan and lifespan through circadian rhythm-dependent activation of autophagy. The night-specific induction of autophagy is both necessary and sufficient for iTRF-mediated health benefits. The study provides the intriguing possibility that novel behavioral or pharmaceutical interventions that promote night-specific autophagy can be used to promote healthy aging.
摘要
自噬在衰老和与年龄相关疾病的发病机制中起着至关重要的作用。在各种动物模型中的研究表明，自噬相关基因在多种抗衰老干预措施中具有保守的需求。Shirasu-Hiza 实验室的一项最新研究表明，一种新设计的间歇性限时喂养（iTRF）饮食方案可以通过昼夜节律依赖性自噬的激活，强有力地延长果蝇的健康寿命和寿命。自噬的夜间特异性诱导对于 iTRF 介导的健康益处是必要且充分的。该研究提出了一种有趣的可能性，即促进夜间特异性自噬的新型行为或药物干预措施可用于促进健康衰老。
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本文引用的文献
1
Autophagy in healthy aging and disease.自噬在健康衰老和疾病中的作用。
Nat Aging. 2021 Aug;1(8):634-650. doi: 10.1038/s43587-021-00098-4. Epub 2021 Aug 12.
2
Circadian autophagy drives iTRF-mediated longevity.昼夜节律性自噬驱动 iTRF 介导的长寿。
Nature. 2021 Oct;598(7880):353-358. doi: 10.1038/s41586-021-03934-0. Epub 2021 Sep 29.
3
Fine-tuning autophagy maximises lifespan and is associated with changes in mitochondrial gene expression in Drosophila.微调自噬可最大限度地延长寿命，并与果蝇中线粒体基因表达的变化有关。
PLoS Genet. 2020 Nov 30;16(11):e1009083. doi: 10.1371/journal.pgen.1009083. eCollection 2020 Nov.
4
From discoveries in ageing research to therapeutics for healthy ageing.从衰老研究的发现到健康衰老的治疗方法。
Nature. 2019 Jul;571(7764):183-192. doi: 10.1038/s41586-019-1365-2. Epub 2019 Jul 10.
5
Autophagy as a promoter of longevity: insights from model organisms.自噬作为长寿的促进因素：来自模式生物的见解。
Nat Rev Mol Cell Biol. 2018 Sep;19(9):579-593. doi: 10.1038/s41580-018-0033-y.
6
Fasting, Circadian Rhythms, and Time-Restricted Feeding in Healthy Lifespan.健康寿命中的禁食、昼夜节律和限时进食
Cell Metab. 2016 Jun 14;23(6):1048-1059. doi: 10.1016/j.cmet.2016.06.001.
7
Time-restricted feeding and risk of metabolic disease: a review of human and animal studies.限时进食与代谢疾病风险：对人类和动物研究的综述
Nutr Rev. 2014 May;72(5):308-18. doi: 10.1111/nure.12104. Epub 2014 Apr 16.
8
Circadian autophagy rhythm: a link between clock and metabolism?昼夜节律性自噬节律：时钟与代谢之间的联系？
Trends Endocrinol Metab. 2012 Jul;23(7):319-25. doi: 10.1016/j.tem.2012.03.004. Epub 2012 Apr 18.
9
Global and regional burden of disease and risk factors, 2001: systematic analysis of population health data.《2001年全球和区域疾病负担及风险因素：对人群健康数据的系统分析》
Lancet. 2006 May 27;367(9524):1747-57. doi: 10.1016/S0140-6736(06)68770-9.
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