Cardiology Unit, Luigi Sacco University Hospital, Milan, Italy.
Cardiology Unit, Luigi Sacco University Hospital, Milan, Italy; Division of Cardiology, Johns Hopkins University, Baltimore, MD, USA.
Card Electrophysiol Clin. 2022 Mar;14(1):95-104. doi: 10.1016/j.ccep.2021.10.009. Epub 2021 Oct 30.
While looking for a solution to treat COVID-19, the massive off-label use of several drugs in COVID-19 has generated concerns in the early phase of the pandemic because of possible arrhythmogenic effects in relation to QTc interval prolongation. Indeed, some of these drugs have been historically associated with QT prolongation and Torsade de Point, a potentially lethal ventricular arrhythmia, and their first-time use on a very large scale has raised several concerns in the scientific community. This work aims to summarize the underlying arrhythmogenic mechanisms related to the use of potentially QT-prolonging drugs used during the pandemic to treat COVID-19.
在寻找治疗 COVID-19 的方法时，大剂量超说明书使用多种 COVID-19 治疗药物在疫情早期引起了关注，因为这些药物可能会导致 QTc 间期延长而产生致心律失常作用。事实上，其中一些药物在历史上与 QT 间期延长和尖端扭转型室性心动过速（一种潜在致命的室性心律失常）有关，在如此大规模的首次使用中，引起了科学界的一些担忧。这项工作旨在总结与在大流行期间用于治疗 COVID-19 的潜在致心律失常药物使用相关的潜在致心律失常机制。
