Högerle Catalina, San Nicolo Marion, Gellrich Donata, Eder Katharina, Gröger Moritz
Department of Otorhinolaryngology, Head and Neck Surgery, Ludwig-Maximilians-University Munich, München, Germany.
J Asthma Allergy. 2022 Feb 19;15:249-255. doi: 10.2147/JAA.S348650. eCollection 2022.
Many plant food allergens contain homologs to the major birch allergen Bet v 1; therefore, the majority of patients with birch pollen allergy suffer from oral allergy syndrome. We studied the relevance of sensitization of Bet v 1 and co-sensitization with profilin concerning the clinical manifestations of an oral allergy syndrome.
A total of 1119 patients with a positive skin prick test to birch and diagnostic for specific IgE to the allergen components Bet v 1 and profilin were analyzed retrospectively regarding complaints in the upper and lower airways, with demographic data as well as oral and gastrointestinal allergy symptoms.
Patients with simultaneous specific IgE to the allergen components Bet v 1 and profilin have to deal more often with an oral allergy syndrome and intestinal reactions. They also suffer more frequently and severely from rhinitis symptoms and show a higher tendency for asthma. No increased number of systemic reactions was seen.
Patients with birch allergy recognizing both allergens have more probabilities of suffering from an oral allergy syndrome, and allergologists should be aware of this in order to give better advice to their patients.
许多植物性食物过敏原含有与主要桦树过敏原Bet v 1的同源物；因此，大多数桦树花粉过敏患者患有口腔过敏综合征。我们研究了Bet v 1致敏以及与肌动蛋白结合蛋白共同致敏与口腔过敏综合征临床表现的相关性。
对1119例对桦树皮肤点刺试验呈阳性且对过敏原成分Bet v 1和肌动蛋白结合蛋白特异性IgE诊断呈阳性的患者进行回顾性分析，内容包括上、下呼吸道症状、人口统计学数据以及口腔和胃肠道过敏症状。
对过敏原成分Bet v 1和肌动蛋白结合蛋白同时存在特异性IgE的患者更常出现口腔过敏综合征和肠道反应。他们也更频繁、更严重地遭受鼻炎症状，并且哮喘倾向更高。未观察到全身反应数量增加。
识别两种过敏原的桦树过敏患者患口腔过敏综合征的可能性更高，过敏症专科医生应意识到这一点，以便为患者提供更好的建议。
