Department of Neuroradiology, Children's National Hospital, 111 Michigan Ave NW, Washington, DC, 20010, USA.
School of Medicine and Health Sciences, The George Washington University, Washington, DC, USA.
Neuroradiology. 2022 Jun;64(6):1111-1126. doi: 10.1007/s00234-022-02918-9. Epub 2022 Feb 28.
Proton MRS of the brain provides the ability to gather direct information regarding the metabolic status of the brain at the time of MRI. Although selective vulnerability of brain tissue may yield distinct imaging patterns in neurometabolic disorders, it is not uncommon for the brain MRI to be normal, nonspecific, or show ambiguous abnormalities among several possible diagnoses, metabolic, or otherwise. This review highlights childhood neurometabolic diseases in which H MRS may show diagnostic or suggestive metabolic profiles without complicated acquisition or postprocessing techniques.
脑部质子磁共振波谱（Proton MRS）能够在进行 MRI 检查的同时，直接获取脑部代谢状态的相关信息。尽管神经代谢紊乱可能导致脑部组织出现选择性易损性，从而产生特定的影像学表现，但在多种可能的诊断（代谢性或其他）中，脑部 MRI 也可能表现为正常、非特异性或显示模棱两可的异常。本综述重点介绍了一些儿童神经代谢性疾病，在这些疾病中，即使没有复杂的采集或后处理技术，磁共振波谱（H MRS）也可能显示出具有诊断或提示意义的代谢特征。
