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表面增强拉曼散射/TERS 光谱学对新型潜在治疗药物的表征：位置异构体、界面类型、铜的氧化态和孵育时间对铜（I）和（II）氧化物纳米粒子表面吸附的影响。

SERS/TERS Characterization of New Potential Therapeutics: The Influence of Positional Isomerism, Interface Type, Oxidation State of Copper, and Incubation Time on Adsorption on the Surface of Copper(I) and (II) Oxide Nanoparticles.

机构信息

Faculty of Foundry Engineering, AGH University of Science and Technology, ul. Reymonta 23, 30-059 Kraków, Poland.

Department of Chemistry, School of Science and Technology, Kwansei Gakuin University, Gakuen 2-1, Sanda, Hyogo 669-137, Japan.

出版信息

J Med Chem. 2022 Mar 10;65(5):4387-4400. doi: 10.1021/acs.jmedchem.2c00031. Epub 2022 Mar 1.

DOI:10.1021/acs.jmedchem.2c00031
PMID:35230122
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8919263/
Abstract

The aim of this study was to investigate how the oxidation state of copper (Cu(I) vs Cu(II)), the nature of the interface (solid/aqueous vs solid/air), positional isomerism, and incubation time affect the functionalization of the surface of copper oxide nanostructures by [(butylamino)(pyridine)methyl]phenylphosphinic acid (PyPA). For this purpose, 2-, 3-, and 4-isomers of PyPA and the nanostructures were synthesized. The nanostructure were characterized by UV-visible spectroscopy (UV-vis), scanning electron microscopy (SEM), Raman spectroscopy (RS), and X-ray diffraction (XRD) analysis, which proved the formation of spherical CuO nanoparticles (CuONPs; 1500-600 nm) and leaf-like CuO nanostructures (CuONSs; 80-180/400-700 nm, width/length). PyPA isomers were deposited on the surface of NSs, and adsorption was investigated by surface-enhanced Raman scattering (SERS) and tip-enhanced Raman scattering (TERS). The changes of adsorption on the surface of copper oxide NSs caused by the above-mentioned factors were described and the enhancement factor on this substrate was calculated.

摘要

本研究旨在探讨铜的氧化态（Cu(I)与 Cu(II)）、界面性质（固/水相与固/气相间）、位置异构体和孵育时间如何影响 (丁氨基)(吡啶基甲基)苯基膦酸对氧化铜纳米结构表面的功能化。为此，合成了 PyPA 的 2-、3-和 4-异构体和纳米结构。通过紫外-可见光谱（UV-vis）、扫描电子显微镜（SEM）、拉曼光谱（RS）和 X 射线衍射（XRD）分析对纳米结构进行了表征，证明了球形 CuO 纳米粒子（CuONPs；1500-600nm）和叶状 CuO 纳米结构（CuONSs；80-180/400-700nm，宽/长）的形成。PyPA 异构体沉积在 NSs 的表面上，并通过表面增强拉曼散射（SERS）和尖端增强拉曼散射（TERS）研究了吸附情况。描述了上述因素引起的氧化铜 NSs 表面吸附的变化，并计算了该基底上的增强因子。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ed9/8919263/b99d1feac54e/jm2c00031_0009.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ed9/8919263/6c6f201023f3/jm2c00031_0007.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ed9/8919263/cb94b2014ba6/jm2c00031_0002.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ed9/8919263/e5f8a883def6/jm2c00031_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ed9/8919263/f243943017a4/jm2c00031_0005.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ed9/8919263/6c6f201023f3/jm2c00031_0007.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ed9/8919263/b99d1feac54e/jm2c00031_0009.jpg

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