波纳瑞多斯 A-M，多样的二萜类化合物，来自于大戟属的铁苋菜。
Phorneroids A-M, diverse types of diterpenoids from Euphorbia neriifolia.
机构信息
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai, 201203, People's Republic of China; Nano Science and Technology Institute, University of Science and Technology of China, Suzhou, Jiangsu, 215123, People's Republic of China.
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai, 201203, People's Republic of China.
出版信息
Phytochemistry. 2022 Jun;198:113142. doi: 10.1016/j.phytochem.2022.113142. Epub 2022 Feb 26.
A chemical investigation on the aerial parts of Euphorbia neriifolia led to the identification of thirteen undescribed diterpenoids, phorneroids A-M, including ent-abietane (A-D), ent-kaurane (E-G), ent-atisane (H-K), and ent-isopimarane (L and M) types, together with three known compounds. Phorneroid A represents the first example of 8-spiro-fused 9,10-seco-ent-abietane diterpenoid lactone featuring a unique 6/5/6/5 spirocyclic framework. Biological assays showed that some of the compounds displayed moderate cytotoxicity against two human tumor cell lines, A549 and HL-60.
对大飞扬草（Euphorbia neriifolia）的地上部分进行的化学研究，鉴定出了 13 种未被描述的二萜类化合物，包括 phorneroids A-M，包括 ent-abietane（A-D）、ent-kaurane（E-G）、ent-atisane（H-K）和 ent-isopimarane（L 和 M）型，以及三种已知的化合物。phorneroid A 是第一个具有独特的 6/5/6/5 螺环骨架的 8-螺合 9,10-去甲-ent-abietane 二萜内酯的例子。生物测定表明，一些化合物对两种人肿瘤细胞系 A549 和 HL-60 表现出中等的细胞毒性。
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