大戟属植物中具抗 HIV 和细胞毒性的二萜类化合物。
Diterpenoids from Euphorbia neriifolia and Their Related Anti-HIV and Cytotoxic Activity.
机构信息
Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, 650500, P. R. China.
出版信息
Chem Biodivers. 2019 Dec;16(12):e1900495. doi: 10.1002/cbdv.201900495. Epub 2019 Nov 22.
Fifteen diterpenoids (1-15), including three undescribed ones with ent-atisane skeleton, eupnerias G-I (1-3), were obtained from Euphorbia neriifolia. Compounds 1-3 were established through comprehensive spectroscopic analysis. Compounds 4 and 5 exhibited obvious anti-HIV-1 effect, and their EC were 6.6±3.2 and 6.4±2.5 μg mL , respectively. Compound 6 exhibited moderate cytotoxicity on HepG2 and HepG2/Adr cells with IC at 13.70 and 15.57 μm, respectively. In addition, compound 15 exhibited significant cytotoxicity on HepG2 cell lines (IC =0.01 μm), while it did not show any cytotoxicity against HepG2/Adr cell lines.
从大戟属植物中分离得到 15 个二萜类化合物（1-15），包括 3 个具有 ent-atisane 骨架的未知化合物，分别命名为 eupnerias G-I（1-3）。通过综合光谱分析确定了化合物 1-3 的结构。化合物 4 和 5 表现出明显的抗 HIV-1 作用，EC 分别为 6.6±3.2 和 6.4±2.5 μg/mL。化合物 6 对 HepG2 和 HepG2/Adr 细胞表现出中等细胞毒性，IC 分别为 13.70 和 15.57 μm。此外，化合物 15 对 HepG2 细胞系表现出显著的细胞毒性（IC=0.01 μm），而对 HepG2/Adr 细胞系没有显示出任何细胞毒性。
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