Technology Innovation Div., Hitachi High-Tech Corporation, Business Tower, Toranomon Hills, 1-17-1 Minato-ku, Toranomon, Tokyo, 105-6409, Japan.
Hitachi Health Care Center, Hitachi Ltd., Ibaraki, Japan.
Sci Rep. 2022 Mar 1;12(1):3359. doi: 10.1038/s41598-022-07398-8.
Several studies suggest the involvement of dietary habits and gut microbiome in allergic diseases. However, little is known about the nutritional and gut microbial factors associated with the risk of allergic rhinitis (AR). We recruited 186 participants with symptoms of AR and 106 control subjects without symptoms of AR at the Hitachi Health Care Center, Japan. The habitual consumption of 42 selected nutrients were examined using the brief-type self-administered diet history questionnaire. Faecal samples were collected and subjected to amplicon sequencing of the 16S ribosomal RNA gene hypervariable regions. Association analysis revealed that four nutrients (retinol, vitamin A, cryptoxanthin, and copper) were negatively associated with AR. Among 40 genera examined, relative abundance of Prevotella and Escherichia were associated with AR. Furthermore, significant statistical interactions were observed between retinol and Prevotella. The age- and sex-adjusted odds of AR were 25-fold lower in subjects with high retinol intake and high Prevotella abundance compared to subjects with low retinol intake and low Prevotella abundance. Our data provide insights into complex interplay between dietary nutrients, gut microbiome, and the development of AR.
一些研究表明，饮食习惯和肠道微生物群与过敏疾病有关。然而，对于与过敏性鼻炎（AR）风险相关的营养和肠道微生物因素知之甚少。我们在日本日立医疗中心招募了 186 名有 AR 症状的参与者和 106 名无症状的对照者。使用简短型自我管理饮食史问卷检查了 42 种选定营养素的习惯性摄入情况。收集粪便样本，并对 16S 核糖体 RNA 基因高变区进行扩增子测序。关联分析显示，有四种营养素（视黄醇、维生素 A、隐黄质和铜）与 AR 呈负相关。在所检查的 40 个属中，普雷沃氏菌属和大肠埃希菌属的相对丰度与 AR 相关。此外，还观察到视黄醇和普雷沃氏菌之间存在显著的统计相互作用。与低视黄醇摄入和低普雷沃氏菌丰度的受试者相比，高视黄醇摄入和高普雷沃氏菌丰度的受试者患 AR 的年龄和性别调整比值比低 25 倍。我们的数据提供了对饮食营养素、肠道微生物群和 AR 发展之间复杂相互作用的深入了解。
