Fan Qin, He Zhimei, Xiong Jinxin, Chao Jie
Key Laboratory for Organic Electronics & Information Displays (KLOEID), Jiangsu Key Laboratory for Biosensors, Institute of Advanced Materials (IAM) and School of Materials Science and Engineering, Nanjing University of Posts & Telecommunications, Nanjing, 210000, P. R. China.
Smart Health Big Data Analysis and Location Services Engineering Research Center of Jiangsu Province, School of Geographic and Biologic Information, Nanjing University of Posts & Telecommunications, Nanjing, 210000, P. R. China.
Chempluschem. 2022 Mar;87(3):e202100548. doi: 10.1002/cplu.202100548. Epub 2022 Feb 14.
The development of DNA nanotechnology has attracted tremendous attention in biotechnological and biomedical fields involving biosensing, bioimaging and disease therapy. In particular, precise control over size and shape, easy modification, excellent programmability and inherent homology make the sophisticated DNA nanostructures vital for constructing intelligent drug carriers. Recent advances in the design of multifunctional DNA-based drug delivery systems (DDSs) have demonstrated the effectiveness and advantages of DNA nanostructures, showing the unique benefits and great potential in enhancing the delivery of pharmaceutical compounds and reducing systemic toxicity. This Review aims to overview the latest researches on DNA nanotechnology-enabled nanomedicine and give a perspective on their future opportunities.
DNA纳米技术的发展在涉及生物传感、生物成像和疾病治疗的生物技术和生物医学领域引起了极大关注。特别是，对尺寸和形状的精确控制、易于修饰、出色的可编程性和内在的同源性使复杂的DNA纳米结构对于构建智能药物载体至关重要。基于多功能DNA的药物递送系统（DDS）设计的最新进展证明了DNA纳米结构的有效性和优势，显示出在增强药物化合物递送和降低全身毒性方面的独特益处和巨大潜力。本综述旨在概述基于DNA纳米技术的纳米医学的最新研究，并展望其未来机遇。
