Division of Maternal-Fetal Medicine, Obstetrics and Gynaecology Department, 16824Puerta del Mar University Hospital, Cádiz, Spain.
Department of Obstetrics and Gynaecology, 16875Puerto Real University Hospital, Puerto Real, Cádiz, Spain & Ginemed Clínicas, San Fernando, Cádiz, Spain.
Diab Vasc Dis Res. 2022 Jan-Feb;19(1):14791641221078109. doi: 10.1177/14791641221078109.
We aimed to evaluate fetal cerebral circulation using three-dimensional power Doppler (3DPD) vascular indices and to study their relationships with maternal lipid and glycaemic profiles.
Case-control study in women with and without gestational diabetes mellitus (GDM) at 28-32 weeks in which feto-maternal Doppler study and 3DPD cerebral vascularization indices (FI, VI and VFI) were determined. Maternal lipid and glycaemic profiles were also analysed. Both groups were compared and the correlations of the 3DPD indices with studied variables were analysed.
There were significant differences between groups in cerebral FI (= 0.02), mean maternal Uterine artery PI (= 0.009) and glucose levels (= 0.001), being higher in the GDM group. Significant negative correlations were found in GDM group between VFI and MCA PI ( = 0.02) and between VI and MCA PI (= 0.01). In the GDM group we found a negative significant correlation between FI, VI, VFI and maternal glucose (r= -0.52, <0.001; r= -0.32, =0.03 and r= -0.36, = 0.01, respectively).
Fetal cerebral FI values were higher in GDM pregnancies. All 3DPD vascular indices showed an inverse correlation with maternal glucose levels. These findings support the view that GDM may also represent a fetal vascular disorder influencing fetal neurodevelopment.
我们旨在使用三维能量多普勒（3DPD）血管指数评估胎儿脑循环，并研究其与母体血脂和血糖谱的关系。
在 28-32 周时对患有和不患有妊娠期糖尿病（GDM）的妇女进行病例对照研究，测定胎儿-母体多普勒研究和 3DPD 脑血管化指数（FI、VI 和 VFI）。还分析了母体血脂和血糖谱。比较两组间的差异，并分析 3DPD 指数与研究变量的相关性。
两组间脑 FI（=0.02）、平均母体子宫动脉 PI（=0.009）和血糖水平（=0.001）存在显著差异，GDM 组较高。在 GDM 组中，VFI 与 MCA PI（=0.02）和 VI 与 MCA PI（=0.01）之间存在显著负相关。在 GDM 组中，我们发现 FI、VI 和 VFI 与母体血糖之间存在负显著相关性（r=-0.52，<0.001；r=-0.32，=0.03 和 r=-0.36，=0.01，分别）。
GDM 妊娠胎儿脑 FI 值较高。所有 3DPD 血管指数均与母体血糖水平呈负相关。这些发现支持 GDM 也可能代表胎儿血管紊乱，影响胎儿神经发育的观点。
