Krempel Rebekka, Schleicher Daniel, Jarvers Irina, Ecker Angelika, Brunner Romuald, Kandsperger Stephanie
Clinic of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University of Regensburg, Germany.
BJPsych Open. 2022 Mar 3;8(2):e57. doi: 10.1192/bjo.2022.29.
Depressive disorders are common mental health problems during adolescence. Many adolescents with depression describe difficulties with sleeping. Findings of previous studies regarding changes in objective sleep quality in adolescents with depressive disorders are heterogeneous.
This study aims to investigate differences in objective and subjective sleep quality between adolescents with depressive disorders and healthy peers, and to evaluate if potential changes in sleep occur concurrently with changes in the release of cortisol and alpha-amylase after awakening.
This non-interventional parallel study examines correlations between depressive disorders, sleep quality and release of stress hormones. Sleep quality in the past 2 weeks, severity of depressive symptoms, psychiatric comorbidities and stress response of 30 adolescents with depressive disorders and 30 healthy controls (N = 60) are assessed via questionnaires. In participants' home environments, the objective sleep quality of seven consecutive nights is measured by sleep accelerometry. After awakening, participants answer sleep questionnaires to examine the subjective sleep quality of those nights. Furthermore, salivary cortisol and alpha-amylase are measured three times after awakening (+0 min, +30 min and +45 min after awakening).
Sleep is an important factor for prognosis and well-being in adolescents with depression. The results of this study can be highly valuable to integrate a more detailed examination of sleep quality and sleeping impairments in the treatment of adolescent depressive disorders.
抑郁症是青少年常见的心理健康问题。许多患有抑郁症的青少年都描述存在睡眠困难。先前关于抑郁症青少年客观睡眠质量变化的研究结果并不一致。
本研究旨在调查抑郁症青少年与健康同龄人在客观和主观睡眠质量上的差异，并评估觉醒后睡眠的潜在变化是否与皮质醇和α-淀粉酶释放的变化同时发生。
这项非干预性平行研究考察了抑郁症、睡眠质量与应激激素释放之间的相关性。通过问卷调查评估30名抑郁症青少年和30名健康对照者（N = 60）过去2周的睡眠质量、抑郁症状严重程度、精神共病情况和应激反应。在参与者家中，通过睡眠加速度计测量连续七个晚上的客观睡眠质量。觉醒后，参与者回答睡眠问卷以检查那些夜晚的主观睡眠质量。此外，觉醒后三次（觉醒后+0分钟、+30分钟和+45分钟）测量唾液皮质醇和α-淀粉酶。
睡眠是抑郁症青少年预后和幸福感的重要因素。本研究结果对于在青少年抑郁症治疗中纳入更详细的睡眠质量和睡眠障碍检查具有很高的价值。
