Department of Veterinary Internal Medicine, College of Veterinary Medicine, Chonnam National University, Gwangju, Republic of Korea.
BK21 Project Team, College of Veterinary Medicine, Chonnam National University, Gwangju, Republic of Korea.
In Vivo. 2022 Mar-Apr;36(2):743-752. doi: 10.21873/invivo.12761.
BACKGROUND/AIM: No study has investigated skin barrier dysfunction with systemic diseases in veterinary medicine. We investigated the mechanism of disturbed skin barrier function in dogs with internal diseases.
Healthy controls and dogs with systemic diseases were enrolled in three different disease groups: malignant tumor, hyperadrenocorticism and kidney disease. Transepidermal water loss (TEWL), serum levels of five selective pro-inflammatory cytokines and claudin-1, and complete blood count were measured.
TEWL was significantly increased in the malignant tumor group while serum claudin-1 concentrations were significantly lower compared to controls. Tumor necrosis factor-α was also significantly increased in the cancer group. In addition, the malignant tumor group showed significantly higher monocyte chemotactic protein-1 after chemotherapy, but lower interleukin-6 levels, compared to dogs with no chemotherapy.
Skin barrier function was decreased in dogs with malignant tumors compared to dogs with other systemic diseases by oxidative stress and a reduction in tight junction proteins.
背景/目的：在兽医医学中，尚无研究调查全身性疾病与皮肤屏障功能障碍之间的关系。我们旨在研究患有内科疾病的犬皮肤屏障功能障碍的发生机制。
将健康对照犬和患有内科疾病的犬纳入三种不同的疾病组：恶性肿瘤、库欣氏病和肾病。测量经皮水分丢失（TEWL）、五种选择性促炎细胞因子和紧密连接蛋白-1的血清水平以及全血细胞计数。
与对照组相比，恶性肿瘤组的 TEWL 显著增加，而血清紧密连接蛋白-1浓度显著降低。癌症组的肿瘤坏死因子-α也显著增加。此外，与未接受化疗的犬相比，接受化疗的恶性肿瘤组的单核细胞趋化蛋白-1明显升高，但白细胞介素-6水平较低。
与患有其他全身性疾病的犬相比，患有恶性肿瘤的犬的皮肤屏障功能通过氧化应激和紧密连接蛋白的减少而降低。
