一种细菌诱导的凝集素，可引发烟草天蛾血细胞凝集。

A bacterial-induced lectin which triggers hemocyte coagulation in Manduca sexta.

作者信息

Minnick M F, Rupp R A, Spence K D

出版信息

Biochem Biophys Res Commun. 1986 Jun 13;137(2):729-35. doi: 10.1016/0006-291x(86)91139-3.

Abstract

An inducible hemagglutinin termed M13, was purified from M. sexta hemolymph. M13 is a glucose-specific lectin which in addition to erythrocyte agglutination, can activate dedifferentiation of various hemocytes into a filamentous coagulation network. When lectin activity was inhibited with glucose or antiserum, neither erythrocyte agglutination or hemocyte coagulation occurred. When M13 was boiled or trypsin treated, hemocyte activation was lost, but erythrocyte agglutination remained. Hence M13 activity appears to be bimodal, possessing both a lectin activity and a hemocyte-coagulating activity.

摘要

一种名为M13的可诱导血凝素从烟草天蛾的血淋巴中纯化得到。M13是一种葡萄糖特异性凝集素，除了能使红细胞凝集外，还能激活各种血细胞去分化形成丝状凝血网络。当凝集素活性被葡萄糖或抗血清抑制时，红细胞凝集和血细胞凝集均不会发生。当M13被煮沸或用胰蛋白酶处理后，血细胞激活作用丧失，但红细胞凝集仍存在。因此，M13的活性似乎是双峰的，兼具凝集素活性和血细胞凝集活性。