De Verno P J, Chadwick J S, Aston W P, Dunphy G B
Dev Comp Immunol. 1984 Summer;8(3):537-46. doi: 10.1016/0145-305x(84)90086-7.
A state of immunity in Galleria mellonella against the pathogen Pseudomonas aeruginosa is known to be induced by the injection of lipopolysaccharide (LPS), isolated from the homologous organism. An in vitro mixture of the LPS and whole or cell-free hemolymph from non-immunized larvae is not antibacterial. In vitro mixtures of fat body and cell-free hemolymph from non-immunized larvae, incubated at 25 degrees C for 20 hours generated a proteinaceous antibacterial activity. The generation of this activity was enhanced by the presence in the incubation mixture of LPS and/or hemocytes from non-immunized larvae. It is suggested that LPS causes the release of a hemocyte factor(s) which acts in conjunction with or directly on the fat body resulting in an enhanced production of antibacterial factors.
已知通过注射从同源生物体中分离出的脂多糖（LPS）可诱导蜡螟对抗铜绿假单胞菌病原体产生免疫状态。LPS与未免疫幼虫的全血淋巴或无细胞血淋巴的体外混合物没有抗菌作用。未免疫幼虫的脂肪体和无细胞血淋巴的体外混合物在25℃下孵育20小时产生了一种蛋白质抗菌活性。LPS和/或未免疫幼虫的血细胞存在于孵育混合物中可增强这种活性的产生。有人认为，LPS会导致血细胞因子的释放，该因子与脂肪体协同作用或直接作用于脂肪体，从而增强抗菌因子的产生。
