Bhamidipati Kartik, Wei Kevin
Department of Medicine, Division of Rheumatology, Inflammation and Immunity, Brigham and Women's Hospital, Harvard Medical School, USA.
Center for Cellular Profiling - Single Cell Multiomics Core, Brigham and Women's Hospital, Harvard Medical School, USA.
Best Pract Res Clin Rheumatol. 2022 Mar;36(1):101742. doi: 10.1016/j.berh.2022.101742. Epub 2022 Mar 2.
Rheumatoid arthritis is an autoimmune disease that causes significant morbidity. Application of cellular profiling techniques such as single-cell transcriptomics and spatial transcriptomics has uncovered novel pathogenic cell types in RA joint tissues and revealed marked heterogeneity in the cellular composition among RA patients. Together, these insights provide exciting opportunities to translate discoveries into precision medicine in RA. The present review aims to highlight novel insights into RA pathology and discuss key steps needed to translate these discoveries into actionable changes in clinical practice. We review the efforts to identify surrogate biomarkers that could be used to predict RA synovial tissue phenotypes and the corresponding responses to therapy. Finally, we discuss the opportunity to develop novel patient-derived organoid systems as a platform for therapeutic target validation.
类风湿性关节炎是一种会导致严重发病的自身免疫性疾病。单细胞转录组学和空间转录组学等细胞分析技术的应用，在类风湿性关节炎关节组织中发现了新的致病细胞类型，并揭示了类风湿性关节炎患者之间细胞组成的显著异质性。这些见解共同为将研究发现转化为类风湿性关节炎的精准医学提供了令人兴奋的机会。本综述旨在突出对类风湿性关节炎病理学的新见解，并讨论将这些发现转化为临床实践中可行变化所需的关键步骤。我们回顾了为识别可用于预测类风湿性关节炎滑膜组织表型及相应治疗反应的替代生物标志物所做的努力。最后，我们讨论了开发新型患者来源类器官系统作为治疗靶点验证平台的机会。
