Kong Jianglong, Zou Rui, Law Ga-Lai, Wang Yi
Department of Chemistry, Hong Kong Baptist University, Kowloon Tung, Hong Kong SAR.
Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Hum, Kowloon, Hong Kong SAR.
Sci Adv. 2022 Mar 11;8(10):eabm7077. doi: 10.1126/sciadv.abm7077. Epub 2022 Mar 9.
Glioma is the most common malignant primary brain tumor, and the accurate diagnosis of glioma has always been a challenge. Moreover, cerebellar glioma, which is difficult to be detected by magnetic resonance imaging, is not usually diagnosed until after the appearance of clinical symptoms. In this study, TRZD, a near-infrared (NIR) persistent luminescence (PL) nanoparticle with a dual function of imaging and therapy, was synthesized based on ZnGaO:Cr,Sn. TRZD showed excellent rechargeable NIR PL for more than 30 hours in vivo with good tissue penetration for long-term autofluorescence-free imaging. The tumor growth of both the subcutaneous and orthotropic glioma models was significantly inhibited by TRZD. This is the first-time approach using NIR PL nanoprobes for both diagnosis and therapy of glioma. This is also the first-time report of nanotechnology-based diagnosis and therapy of cerebellar gliomas. This study offers a highly promising multifunctional nanoparticle for theranostics of a wide range of brain diseases.
胶质瘤是最常见的原发性恶性脑肿瘤，准确诊断胶质瘤一直是一项挑战。此外，磁共振成像难以检测到的小脑胶质瘤，通常直到出现临床症状后才被诊断出来。在本研究中，基于ZnGaO:Cr,Sn合成了具有成像和治疗双重功能的近红外（NIR）持续发光（PL）纳米颗粒TRZD。TRZD在体内表现出超过30小时的优异可再充电近红外PL，具有良好的组织穿透性，可进行长期无自发荧光成像。皮下和原位胶质瘤模型的肿瘤生长均被TRZD显著抑制。这是首次使用近红外PL纳米探针进行胶质瘤的诊断和治疗。这也是首次报道基于纳米技术的小脑胶质瘤诊断和治疗。本研究为广泛的脑部疾病的诊疗提供了一种极具前景的多功能纳米颗粒。
