Park Soo Hyun, Koyano Kenji W, Russ Brian E, Waidmann Elena N, McMahon David B T, Leopold David A
Section on Cognitive Neurophysiology and Imaging, National Institute of Mental Health, Bethesda, MD, USA.
Neurophysiology Imaging Facility, National Institute of Mental Health, National Institute of Neurological Disorders and Stroke, National Eye Institute, Bethesda, MD, USA.
Sci Adv. 2022 Mar 11;8(10):eabm2054. doi: 10.1126/sciadv.abm2054. Epub 2022 Mar 9.
During normal vision, our eyes provide the brain with a continuous stream of useful information about the world. How visually specialized areas of the cortex, such as face-selective patches, operate under natural modes of behavior is poorly understood. Here we report that, during the free viewing of movies, cohorts of face-selective neurons in the macaque cortex fractionate into distributed and parallel subnetworks that carry distinct information. We classified neurons into functional groups on the basis of their movie-driven coupling with functional magnetic resonance imaging time courses across the brain. Neurons from each group were distributed across multiple face patches but intermixed locally with other groups at each recording site. These findings challenge prevailing views about functional segregation in the cortex and underscore the importance of naturalistic paradigms for cognitive neuroscience.
在正常视觉过程中，我们的眼睛为大脑提供关于世界的持续有用信息流。皮质的视觉特化区域，如面部选择性区域，在自然行为模式下如何运作，目前还知之甚少。在此我们报告，在自由观看电影期间，猕猴皮质中面部选择性神经元群体会分离成携带不同信息的分布式并行子网。我们根据神经元与全脑功能磁共振成像时间进程的电影驱动耦合，将神经元分类为功能组。每组神经元分布在多个面部区域，但在每个记录位点局部与其他组混合。这些发现挑战了关于皮质功能分离的主流观点，并强调了自然主义范式对认知神经科学的重要性。
