Lu Xiang, Wang Hao, Zhang Jingqi, Jin Kexin, Ma Ling, Wang Yan, Yang Shixing, Wang Xiaochun, Shen Quan, Zhou Tianji, Xu Hui, Zhang Wen
Department of Dermatology, The Affiliated Hospital of Jiangsu University, Zhenjiang, China.
Department of Microbiology, School of Medicine, Jiangsu University, Zhenjiang, China.
Front Med (Lausanne). 2022 Feb 21;9:835467. doi: 10.3389/fmed.2022.835467. eCollection 2022.
The immune development and regulation of living individuals are affected by the gut microbiota. The imbalance of gut microbiota is considered to be a key factor that easily induces immune dysregulation and the development of atopic diseases. Atopic dermatitis (AD) is a chronic inflammatory skin disease that affects nearly 20% of children. To date, metagenomics research on AD has mainly focused on the skin and gut microbiome. However, here we assessed the composition of the virome in the gut of AD patients and healthy controls for the first time. This study has obtained possible dominant viruses at different viral classification levels. In terms of diversity, the alpha diversity of the patients group was significantly lower than that of the healthy controls group, and the beta diversity of the two groups was significantly different from phylum to family level. These findings provide a new perspective for us to better understand the effect of the gut microecological environment on AD.
个体的免疫发育和调节受肠道微生物群的影响。肠道微生物群的失衡被认为是易诱发免疫失调和特应性疾病发展的关键因素。特应性皮炎（AD）是一种慢性炎症性皮肤病，影响近20%的儿童。迄今为止，关于AD的宏基因组学研究主要集中在皮肤和肠道微生物组。然而，在此我们首次评估了AD患者和健康对照者肠道中的病毒组组成。本研究在不同病毒分类水平上获得了可能的优势病毒。在多样性方面，患者组的α多样性显著低于健康对照组，两组的β多样性在门到科水平上有显著差异。这些发现为我们更好地理解肠道微生态环境对AD的影响提供了新的视角。
