Shin Younghyun, Kim Dajung, Hu Yiluo, Kim Yohan, Hong In Ki, Kim Moo Sung, Jung Seunho
Center for Biotechnology Research in UBITA (CBRU), Department of Bioscience and Biotechnology, Konkuk University, Seoul 05029, Korea.
Covergence Technology Laboratory, Kolmar Korea, 61, Heolleung-ro-8-gil, Seocho-gu, Seoul 06800, Korea.
Polymers (Basel). 2021 Sep 21;13(18):3197. doi: 10.3390/polym13183197.
Carboxymethyl cellulose (CMC)-based hydrogels are generally superabsorbent and biocompatible, but their low mechanical strength limits their application. To overcome these drawbacks, we used bacterial succinoglycan (SG), a biocompatible natural polysaccharide, as a double crosslinking strategy to produce novel interpenetrating polymer network (IPN) hydrogels in a non-bead form. These new SG/CMC-based IPN hydrogels significantly increased the mechanical strength while maintaining the characteristic superabsorbent property of CMC-based hydrogels. The SG/CMC gels exhibited an 8.5-fold improvement in compressive stress and up to a 6.5-fold higher storage modulus (G') at the same strain compared to the CMC alone gels. Furthermore, SG/CMC gels not only showed pH-controlled drug release for 5-fluorouracil but also did not show any cytotoxicity to HEK-293 cells. This suggests that SG/CMC hydrogels could be used as future biomedical biomaterials for drug delivery.
基于羧甲基纤维素（CMC）的水凝胶通常具有高吸水性和生物相容性，但其低机械强度限制了它们的应用。为了克服这些缺点，我们使用细菌琥珀聚糖（SG），一种生物相容性天然多糖，作为双重交联策略来制备非珠状的新型互穿聚合物网络（IPN）水凝胶。这些新型基于SG/CMC的IPN水凝胶在保持基于CMC的水凝胶的高吸水性特性的同时，显著提高了机械强度。与单独的CMC凝胶相比，SG/CMC凝胶在相同应变下的压缩应力提高了8.5倍，储能模量（G'）高出6.5倍。此外，SG/CMC凝胶不仅显示出对5-氟尿嘧啶的pH控制药物释放，而且对HEK-293细胞没有任何细胞毒性。这表明SG/CMC水凝胶可作为未来用于药物递送的生物医学生物材料。
